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Covid-19 - endothelial axis and coronary artery bypass graft patency: a target for therapeutic intervention?
Topal, Gokce; Loesch, Andrzej; Dashwood, Michael R.
  • Topal, Gokce; Istanbul University. Faculty of Pharmacy. Department of Pharmacology. Istanbul. TR
  • Loesch, Andrzej; University College Medical School. Royal Free Hospital Campus. Centre for Rheumatology. London. GB
  • Dashwood, Michael R; University College Medical School. Royal Free Hospital Campus. Department of Surgical and Interventional Sciences. London. GB
Rev. bras. cir. cardiovasc ; 35(5): 757-763, Sept.-Oct. 2020. tab, graf
Article in English | LILACS, SES-SP | ID: biblio-1137320
ABSTRACT
Abstract It has been reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces endothelial inflammation, therefore facilitating the progression of endothelial and vascular dysfunction in coronavirus disease 2019 (COVID-19) patients. Coronary artery bypass grafting (CABG) involves mainly the use of the saphenous vein (SV) and internal mammary artery as graft material in the stenosed coronary arteries. Unfortunately, graft patency of the SV is low due to endothelial dysfunction and inflammation. We propose that SARS-CoV-2 might cause vascular inflammation, endothelial dysfunction, and thrombosis in coronary artery bypass graft vessels by binding angiotensin-converting enzyme 2 receptor. Therefore, in this Special Article, we consider the potential influence of COVID-19 on the patency rates of coronary artery bypass graft vessels, mainly with reference to the SV. Moreover, we discuss the technique of SV graft harvesting and the therapeutic potential of focusing on endothelial dysfunction, vascular inflammation, and thrombosis for protecting coronary artery bypass grafts in COVID-19 infected CABG patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Vascular Patency / Coronary Artery Bypass / Coronavirus Infections / Graft Occlusion, Vascular Limits: Humans Language: English Journal: Rev. bras. cir. cardiovasc Year: 2020 Type: Article Institution/Affiliation country: Istanbul University/TR / University College Medical School/GB

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Full text: Available Index: LILACS (Americas) Main subject: Vascular Patency / Coronary Artery Bypass / Coronavirus Infections / Graft Occlusion, Vascular Limits: Humans Language: English Journal: Rev. bras. cir. cardiovasc Year: 2020 Type: Article Institution/Affiliation country: Istanbul University/TR / University College Medical School/GB