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Antifungal efficacy of amphotericin b in candida albicans endocarditis therapy: systematic review
Bezerra, Lucas Soares; Silva, Janielli Assis da; Santos-Veloso, Marcelo Antônio Oliveira; Lima, Sandro Gonçalves de; Chaves-Markman, Ândrea Virgínia; Jucá, Moacir Batista.
  • Bezerra, Lucas Soares; Centro Universitário Mauricio de Nassau. Recife. BR
  • Silva, Janielli Assis da; Centro Universitário Mauricio de Nassau. Recife. BR
  • Santos-Veloso, Marcelo Antônio Oliveira; Universidade Federal de Pernambuco. Centro de Biociências. Recife. BR
  • Lima, Sandro Gonçalves de; Centro Universitário Mauricio de Nassau. Recife. BR
  • Chaves-Markman, Ândrea Virgínia; Centro Universitário Mauricio de Nassau. Recife. BR
  • Jucá, Moacir Batista; Centro Universitário Mauricio de Nassau. Recife. BR
Rev. bras. cir. cardiovasc ; 35(5): 789-796, Sept.-Oct. 2020. tab, graf
Article in English | LILACS, SES-SP | ID: biblio-1137325
Responsible library: BR1.1
ABSTRACT
Abstract

Introduction:

Although it is the most common agent among the fungal causes of endocarditis, Candida albicans endocarditis is rare.

Objective:

To evaluate the efficacy of amphotericin B in the treatment of C. albicans endocarditis beyond a systematic review. Data search Articles in English, Spanish and Portuguese, conducted in the following databases MEDLINE, LILACS, IBECS and SciELO, in humans and published in the last 25 years. Study selection Observational studies, clinical trials, and case series providing data on the amphotericin B use in patients with a C. albicans endocarditis diagnosis without age limitations. Data

synthesis:

From the initial search (n=79), 25 articles were fully evaluated, of which 19 were excluded for meeting one or more exclusion criteria, remaining five articles (two observational studies and three case series). Patients using amphotericin B demonstrated improvement in survival rates, and its main use was in association with the surgical method as well as with caspofungin association.

Conclusion:

Literature lacks evidence to conclude about efficacy and safety of amphotericin B in the treatment of fungal endocarditis. Randomized clinical trials are necessary to provide better evidence on the subject.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Candida albicans / Amphotericin B / Endocarditis / Antifungal Agents Type of study: Controlled clinical trial / Systematic reviews Limits: Child / Humans / Infant, Newborn Language: English Journal: Rev. bras. cir. cardiovasc Year: 2020 Type: Article Institution/Affiliation country: Centro Universitário Mauricio de Nassau/BR / Universidade Federal de Pernambuco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Candida albicans / Amphotericin B / Endocarditis / Antifungal Agents Type of study: Controlled clinical trial / Systematic reviews Limits: Child / Humans / Infant, Newborn Language: English Journal: Rev. bras. cir. cardiovasc Year: 2020 Type: Article Institution/Affiliation country: Centro Universitário Mauricio de Nassau/BR / Universidade Federal de Pernambuco/BR