Riesgo de Desarrollo y Progresión de Cáncer Tiroideo Bien Diferenciado en pacientes con Variantes Genéticas del Gen de Tiroglobulina SER 734ala y ARG1980trp / Risk of Development and Progression of Well Differentiated Thyroid Cancer in patients with Genetic Variations of the Thyroglobulin SER734ala and ARG1980trp Genes

RESUMEN

Introducción: Existen factores de riesgo que se asocian a desarrollo cáncer de tiroides diferenciado; la Tiroglobulina es una proteína ligada al tamaño tumoral, su rol dentro de las patologías oncológicas es controversial. El objetivo del estudio fue determinarsi las variaciones del gen de Tiroglobulina se asocian a la presencia de cáncer tiroideo. Métodos:Este estudio observacional de casos y controles se realizó con muestra no probabilística con muestras de patología de casos de cáncertiroideo diagnosticados en elHospital Oncológico Solón Espinosa Ayala de Quito. Se estableció un grupocontrol con voluntarios sanos. Se mide las variaciones SER734Ala y ARG1980 trp del gen de la Tiroglobulina. Se comparan las frecuencias con Chi cuadrado. Resultados:Un total de 51casos de cáncertiroideo y 50 controles. Variaciones en SER734Ala en el grupo de casos fueron homocigotos 24/51casos (53.3% (IC95% 38.8 -67.9%)en el grupo controlfueron24/50(53.3% (IC95% 38.8-67.9%)P=0.83. La variaciónheterocigotaARG1980 trp fueron en el grupo de casos 47/51(92.2%IC95% 84.3 -100%), en los controles 35/50(70% IC95% 56.6-83.4%)P=0.004. Conclusión:Se demostró que lasvariaciones del gen de laTiroglobulina pueden presentarse en pacientes con Cáncer Tiroideo en igual frecuencia que en voluntarios sanos

ABSTRACT

Introduction: There are risk factors associated with the development of differentiated thyroid cancer; Thyroglobulin is a protein linked to tumor size, its role in oncological pathologies is controversial. The objective of the study was to determine whether variations in the thyroglobulin gene are associated with the presence of thyroid cancer. Methods: This observational case-control study was conducted with a non-probabilistic sample with pathology samples from thyroid cancer cases diagnosed at the Solón Espinosa Ayala Oncological Hospital in Quito. A control group with healthy volunteers was established. The SER734Ala and ARG1980 trp variations of the Thyroglobulin gene are measured. The frequencies werecompared with Chi square. Results:A total of 51 thyroid cancer cases and 50 controls. Variations in SER734Ala in the group of cases were homozygous 24/51 cases (53.3% (CI95% 38.8 -67.9%) in the control group were 24/50 (53.3% (CI95% 38.8-67.9%) P = 0.83. Heterozygous ARG1980 trp were in the case group 47/51 (92.2% 95% CI 84.3 -100%), in the controls 35/50 (70% 95% CI 56.6-83.4%) P = 0.004. Conclusion:It was shown that variations of the Thyroglobulin gene couldoccur in patients with Thyroid Cancer in the same frequency as in healthy volunteers