A modified rabbit model of tracheal stenosis and a household endoscope. More simplicity and accessibility
Acta cir. bras
;
35(11): e351104, 2020. graf
Article
in English
| LILACS
| ID: biblio-1141934
ABSTRACT
Abstract Purpose:
To develop a simpler animal model for benign tracheal stenosis and introduce a low-cost household endoscope for postmodeling endotracheal evaluation.Methods:
Twenty rabbits were randomly divided into a model group (15 rabbits, subjected to transoral nylon brush scraping of the trachea) and a mock group (5 rabbits, merely exempted from scraping), a household endoscope was then introduced for weekly endoscopic examination. Meanwhile, other 15 rabbits (modeling like the model group) underwent batch tracheal resection at different postintervention times for pathological analysis.Results:
The model group presented a low mortality and few complications. The endoscope could obtain adequate images for stenosis assessment, which showed that the models presented homogeneous injury after scraping and developed a mature scar stricture at 28 days postoperatively with a mean stenosis degree of 65.9%, and 71.4% (10/14) above Myer-Cotton's grade II. The pathological findings were consistent with the clinicopathological process of human. No stenosis was found in mock group.Conclusion:
The modified model is simpler, minimally invasive and reliable, while the household endoscope is competent for model's follow-up, providing easily accessible and useful tools for facilitating more extensive studies of benign tracheal stenosis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tracheal Stenosis
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2020
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Hospital of Fujian Medical University/CN
/
Quanzhou First Hospital of Fujian Medical University/CN
/
The Second Affiliated Hospital of Fujian Medical University/CN
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