Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis - A position paper of the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Stomatology and Oral Pathology (Sobep), and Brazilian Association for Bone Evaluation and Osteometabolism (Abrasso)
Arch. endocrinol. metab. (Online)
;
64(6): 664-672, Nov.-Dec. 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1142212
ABSTRACT
ABSTRACT Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs. Physicians and dentists caring for patients taking these drugs and requiring invasive procedures face a difficult decision because of the potential risk of MRONJ. The aim of this study was to discuss the risk factors for the development of MRONJ and prevention of this complication in patients with osteoporosis taking antiresorptive drugs and requiring invasive dental treatment. For this goal, a task force with representatives from three professional associations was appointed to review the pertinent literature and discuss systemic and local risk factors, prevention of MRONJ in patients with osteoporosis, and management of established MRONJ. Although scarce evidence links the use of antiresorptive agents in the context of osteoporosis to the development of MRONJ, these agents are considered a risk factor for this complication. Despite the rare reports of MRONJ in patients with osteoporosis, the severity of symptoms and impact of MRONJ in the patients' quality of life make it imperative for health care professionals to consider this complication when planning invasive dental procedures.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Osteoporosis
/
Oral Medicine
/
Bone Density Conservation Agents
/
Bisphosphonate-Associated Osteonecrosis of the Jaw
Type of study:
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Arch. endocrinol. metab. (Online)
Journal subject:
Endocrinology
/
Metabolism
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Centro Universitário de Belo Horizonte/BR
/
Secretaria Municipal de Saúde do Rio de Janeiro/BR
/
Universidade Federal de São Paulo/BR
/
Universidade Federal do Ceará/BR
/
Universidade Federal do Paraná/BR
/
Universidade Federal do Rio de Janeiro/BR
/
Universidade Federal/BR
/
Universidade de Pernambuco/BR
/
Universidade de São Paulo/BR
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