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Primary headache subtypes and thyroid dysfunction: Is there any association? / Subtipos de cefaleia primária e disfunção tireoidiana: existe alguma associação?
Spanou, Ioanna; Christidi, Foteini; Liakakis, Georgios; Rizonaki, Konstantina; Bougea, Anastasia; Anagnostou, Evangelos; Kararizou, Evangelia.
  • Spanou, Ioanna; National and Kapodistrian University of Athens. Medical School. Aeginition Hospital. Athens. GR
  • Christidi, Foteini; National and Kapodistrian University of Athens. Medical School. Aeginition Hospital. Athens. GR
  • Liakakis, Georgios; National and Kapodistrian University of Athens. Medical School. Aeginition Hospital. Athens. GR
  • Rizonaki, Konstantina; National and Kapodistrian University of Athens. Medical School. Aeginition Hospital. Athens. GR
  • Bougea, Anastasia; National and Kapodistrian University of Athens. Medical School. Aeginition Hospital. Athens. GR
  • Anagnostou, Evangelos; National and Kapodistrian University of Athens. Medical School. Aeginition Hospital. Athens. GR
  • Kararizou, Evangelia; National and Kapodistrian University of Athens. Medical School. Aeginition Hospital. Athens. GR
Arq. neuropsiquiatr ; 78(11): 695-699, Nov. 2020. tab, graf
Article in English | LILACS | ID: biblio-1142361
ABSTRACT
ABSTRACT

Background:

Primary headaches, and particularly migraine and tension-type headache (TTH) as well as hypothyroidism are common medical conditions. To date, numerous studies have suggested a possible bidirectional relationship between migraine and hypothyroidism, although certain studies had contradictory results.

Objective:

To investigate whether there is any association between primary headache subtypes and thyroid disorders.

Methods:

A retrospective study of consecutive patients aged ≥18 years referred to the Headache Outpatient Clinic of Aeginition Hospital and diagnosed with primary headache and any thyroid disorder.

Results:

Out of 427 patients (males/females=76/351), 253 (59.3%) were diagnosed with migraine without aura, 53 (12.4%) with TTH, 49 (11.5%) with migraine with aura, 29 (6.8%) with medication-overuse headache, 23 (5.4%) with mixed-type headache (migraine with/without aura and TTH), nine (2.1%) with cluster headache, and 11 (2.6%) with other types of primary headaches. The prevalence of any type of thyroid disorder was 20.8% (89/427 patients). In the total sample, 27 patients (6.3%) reported hypothyroidism, 18 (4.2%) unspecified thyroidopathy, 14 (3.3%) thyroid nodules, 12 (2.8%) Hashimoto thyroiditis, 12 (2.8%) thyroidectomy, three (0.7%) thyroid goiter, and three (0.7%) hyperthyroidism. Further statistical analysis between categorical variables did not reveal any significant association between headache subtypes and thyroid dysfunction.

Conclusions:

No specific association was found between primary headache subtypes and specific thyroid disorder. However, a high prevalence of thyroid dysfunction in general and specifically hypothyroidism was demonstrated among patients with primary headaches, which lays the foundation for further clarification in prospective longitudinal studies.
RESUMO
RESUMO

Introdução:

Cefaleias primárias e, particularmente, enxaqueca e cefaleia do tipo tensional (CTT), bem como hipotiroidismo, constituem condições médicas comuns. Até o momento, vários estudos sugeriram uma possível relação bidirecional entre enxaqueca e hipotireoidismo, embora alguns estudos tenham resultados contraditórios.

Objetivo:

Investigar se existe associação entre subtipos de cefaleia primária e distúrbios da tireoide.

Métodos:

Estudo retrospectivo de pacientes consecutivos com idade ≥18 anos encaminhados ao Ambulatório de Cefaleia do Hospital Aeginition, com diagnóstico de cefaleia primária e qualquer distúrbio da tireoide.

Resultados:

De 427 pacientes (homens/mulheres=76/351), 253 pacientes (59,3%) foram diagnosticados com enxaqueca sem aura, 53 (12,4%) com CTT, 49 (11,5%) com enxaqueca com aura, 29 (6,8 %) com cefaleia por uso excessivo de medicamentos, 23 (5,4%) com cefaleia mista (enxaqueca com/sem aura e CTT), nove (2,1%) com cefaleia em salvas e 11 (2,6%) com outros tipos de cefaleias primárias. A prevalência de qualquer tipo de distúrbio tireoidiano foi de 20,8% (89/427 pacientes). Na amostra total, 27 pacientes (6,3%) relataram hipotireoidismo, 18 (4,2%) tireoidopatia não especificada, 14 (3,3%) nódulos de tireoide, 12 (2,8%) tireoidite de Hashimoto, 12 (2,8%) tireoidectomia, três (0,7%) bócio da tireoide e três (0,7%) hipertireoidismo. Uma análise estatística posterior entre as variáveis categóricas não revelou qualquer associação significativa entre os subtipos de cefaleia e disfunção tireoidiana.

Conclusões:

Não encontramos associação entre subtipos de cefaleia primária e distúrbio específico da tireoide. No entanto, foi observada prevalência elevada de disfunção tireoidiana em geral e especificamente hipotireoidismo entre pacientes com cefaleia primária, o que estabelece base para maiores esclarecimentos em estudos longitudinais prospectivos.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Tension-Type Headache / Headache Disorders, Primary Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2020 Type: Article Affiliation country: Greece Institution/Affiliation country: National and Kapodistrian University of Athens/GR

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Full text: Available Index: LILACS (Americas) Main subject: Tension-Type Headache / Headache Disorders, Primary Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2020 Type: Article Affiliation country: Greece Institution/Affiliation country: National and Kapodistrian University of Athens/GR