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A pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) (NET and undifferentiated carcinoma of the pancreas with osteoclast-like giant cells) with metastatic neuroendocrine component to the liver
Gao, Guofeng; Qorbani, Amir; Zhou, Chihong Heidi.
  • Gao, Guofeng; University of California. Davis Medical Center. Department of Pathology & Laboratory Medicine. Sacramento. US
  • Qorbani, Amir; University of California. San Francisco Medical Center. Department of Pathology & Laboratory Medicine. San Francisco. US
  • Zhou, Chihong Heidi; University of California. Davis Medical Center. Department of Pathology & Laboratory Medicine. Sacramento. US
Autops. Case Rep ; 11: e2020201, 2021. tab, graf
Article in English | LILACS | ID: biblio-1142397
Responsible library: BR26.7
ABSTRACT
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCOGCs) is an extremely rare morphologically and clinically distinct variant of pancreatic ductal adenocarcinoma (PDAC), exhibiting a characteristic component of reactive osteoclast-like giant cells admixed with neoplastic mononuclear cells. Sommers and Meissner first described it in 1954 as an "unusual carcinoma of the pancreas". Later it acquired many different names. In 2010, the WHO classified these tumors as a variant of PDAC under the heading of "undifferentiated carcinoma with osteoclast-like giant cells". Here we describe the first case of pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) composed of UCOGC and pancreatic neuroendocrine tumor (NET), which occurred in a 78-year-old man with biliary colic and pancreatitis. The mass did not respond to the chemotherapy, and he soon developed liver metastasis from the NET component, and unfortunately, the patient passed away 10 months later. Since UCOGC is extremely rare, and its association with NET has not been reported yet, our case expands the knowledge regarding its unusual presentation and poor prognosis.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pancreatic Neoplasms / Neuroendocrine Tumors / Carcinoma, Pancreatic Ductal Type of study: Case report Limits: Aged / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: United States Institution/Affiliation country: University of California/US

Full text: Available Index: LILACS (Americas) Main subject: Pancreatic Neoplasms / Neuroendocrine Tumors / Carcinoma, Pancreatic Ductal Type of study: Case report Limits: Aged / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: United States Institution/Affiliation country: University of California/US