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Secretory carcinoma of the breast, commonly exhibits the features of low grade, triple negative breast carcinoma- A Case report with updated review of literature
Banerjee, Nirmalya; Banerjee, Devmalya; Choudhary, Neha.
  • Banerjee, Nirmalya; Postgraduate Institute of Medical Education and Research. Department of Histopathology. Chandigarh. IN
  • Banerjee, Devmalya; Faculty Department of Oncopathology. NH super-specialty Hospital Howrah. West Bengal. IN
  • Choudhary, Neha; Faculty Department of Oncosurgery. NH super-specialty Howrah. West Bengal. IN
Autops. Case Rep ; 11: e2020227, 2021. tab, graf
Article in English | LILACS | ID: biblio-1142414
ABSTRACT
Secretory carcinoma of the breast (SBC) is a rare breast neoplasm. Most of the patients present at an early stage with a relatively indolent clinical course. Lymph node and distant metastasis are also very infrequent. The histomorphological features of the secretory breast carcinoma are quite characteristic. Predominantly three histological patterns, solid, microcystic, and tubular, have been noted with copious amounts of intra and extracellular secretory material. Most commonly, no positivity for estrogen receptor (ER), progesterone receptor (PR) and ERBB2(HER2/neu) is observed in SBCs. As SBC can occasionally be hormone receptor-positive, they should not be categorized in the triple-negative breast carcinoma (TNBC) group in general. A very characteristic genetic translocation t (12;15) has been noted in this rare tumor, resulting in a fusion between ETV6 and NTRK3 proteins. We present a case of a 60-year-old lady who presented with right breast lump of 1-month duration and was managed by lumpectomy and sentinel lymph node dissection. Axillary dissection was not performed because the sentinel lymph node biopsy was negative. Postoperative radiotherapy was given to the right breast with a boost to the tumor bed. No adjuvant chemotherapy was given No recurrence has been noted even after a year of the completion of treatment
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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Carcinoma Limits: Female / Humans Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: India Institution/Affiliation country: Faculty Department of Oncopathology/IN / Faculty Department of Oncosurgery/IN / Postgraduate Institute of Medical Education and Research/IN

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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Carcinoma Limits: Female / Humans Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: India Institution/Affiliation country: Faculty Department of Oncopathology/IN / Faculty Department of Oncosurgery/IN / Postgraduate Institute of Medical Education and Research/IN