Extract of Solidago chilensis Meyen inflorescences: cytotoxicity and inhibitory activity on nitric oxide synthesis in activated macrophage cell line J774A. 1
Braz. J. Pharm. Sci. (Online)
;
56: e17707, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1142495
ABSTRACT
Solidago chilensis Meyen (= Solidago microglossa) popularly known as "Brazilian arnica" is used to treat of inflammatory disorders. S. chilensis is constant in the Therapeutic Memento of the Rio de Janeiro city and belongs to the medicinal species of Brazilian National List of Medicinal Plants of Interest of the Unified National Health System (SUS). There are no studies in the literature showing the direct activity of this plant species on immune system cells. The present study evaluated the chemical composition as well as the cytotoxic and pharmacological activity of the ether-ethanol extract from S. chilensis inflorescences (SCIE) in murine macrophage cell line J774A.1. The results showed that higher concentrations (50 to 200 µg/mL) of SCIE had significant cytotoxicity on J774A.1 cells, however, lower concentrations (from 10 to 0.1 µg/mL) did not produce significant cytotoxic effects and exhibited an inhibitory effect on nitric oxide production in LPS-stimulated J774A.1 cell line. The chemical analysis by HPLC-UV-PDA indicated that the SCIE contains flavonoid derived from quercetin and kaempferol; and diterpenes, probably labdanes. These findings complement data in the literature regarding the activity of this plant species on an important cell from the immune system involved in the innate and acquired immune response, the macrophages.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plants, Medicinal
/
Plant Extracts
/
Arnica
/
Asteraceae
Country/Region as subject:
South America
/
Chile
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto Nacional de Controle de Qualidade em Saúde - FIOCRUZ/BR
/
Instituto Oswaldo Cruz - FIOCRUZ/BR
/
Instituto de Tecnologia em Fármacos - FIOCRUZ/BR
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