Immune response in SARS-CoV-2 infection: the role of interferons type I and type III
Braz. j. infect. dis
;
24(5): 428-433, Sept.-Oct. 2020.
Article
in English
| LILACS, ColecionaSUS
| ID: biblio-1142549
ABSTRACT
Abstract Background There is scarce information on the human immune response to the SARS-CoV-2 infection, and on the exacerbated inflammatory reaction observed in severe COVID-19 cases. Objective To review the available evidence on the role of interferons type I and type III to SARS-CoV-2 infection. Methods We reviewed the available published evidence on the role of immune response to SARS-CoV-2 infection as well as recent publications on characteristics and outcomes of COVID-19, and their relationship with interferons type I and type III. Results The available data indicates that immune response plays an important role in controlling SARS-CoV-2 infection and the immune dysregulation can significantly modify the clinical outcomes of affected patients. In addition, the evidence suggests that IFN type I and III can play an important role in controlling viremia and modulating the immune response in COVID-19. Conclusions Due to their central role in immune response against SARS-CoV-2 infection, IFN type I and III could be considered for treatment of COVID-19.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pneumonia, Viral
/
Interferon Type I
/
Coronavirus Infections
/
Pandemics
/
Betacoronavirus
Limits:
Humans
Language:
English
Journal:
Braz. j. infect. dis
Year:
2020
Type:
Article
Institution/Affiliation country:
Universidade Federal da Bahia/BR
/
Universidade Federal do Piauí/BR
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