Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
Braz. j. infect. dis
;
24(5): 405-411, Sept.-Oct. 2020. tab, graf
Article
in English
| LILACS, ColecionaSUS
| ID: biblio-1142555
ABSTRACT
Abstract Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in Brazil since early 2015, eventually spreading to other countries on the South American continent. The present study describes the clinical manifestations and laboratory findings of patients with confirmed acute ZIKV infection during the first epidemic that occurred in Salvador, Brazil. All included patients were seen at the emergency room of a private tertiary hospital located in Salvador, Brazil from 2015 through 2017. Patients were considered eligible if signs of systemic viral febrile disease were present. All individuals were tested for ZIKV and Chikungunya infection using PCR, while rapid test was used to detect Dengue virus antibodies or, alternatively, the NS1 antigen. A diagnosis of acute ZIKV infection was confirmed in 78/434 (18%) individuals with systemic viral febrile illness. Positivity was mainly observed in blood, followed by saliva and urine. Coinfection with Chikungunya and/or Dengue virus was detected in 5% of the ZIKV-infected patients. The most frequent clinical findings were myalgia, arthralgia and low-grade fever. Laboratory analysis demonstrated normal levels of hematocrit, platelets and liver enzymes. In summary, in acute settings where molecular testing remains unavailable, clinicians face difficulties to confirm the diagnosis of ZIKV infection, as they rely only on clinical examinations and conventional laboratory tests.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Chikungunya virus
/
Dengue
/
Dengue Virus
/
Epidemics
/
Chikungunya Fever
/
Zika Virus
/
Zika Virus Infection
Type of study:
Diagnostic study
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. infect. dis
Year:
2020
Type:
Article
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR
/
UniFTC/BR
/
Universidade Federal da Bahia/BR
/
Université Pierre Marie-Curie/FR
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