IIncreased serum expression of inflammatory cytokines may serve as potential diagnostic biomarker for bilirubin encephalopathy
Clinics
;
75: e1868, 2020. graf
Article
in English
| LILACS
| ID: biblio-1142771
ABSTRACT
OBJECTIVES:
The present study was designed to explore the roles of inflammatory cytokines interleukin-1β (IL-1β) and Tumor growth factor-β (TGF-β) in the diagnosis and treatment of neonate bilirubin encephalopathy (BE).METHODS:
A total of 128 BE neonates and 128 normal neonates were included. The serum samples of the BE children and controls were collected, and the levels of IL-1β and TGF-β were examined. Moreover, the correlation between the level of bilirubin and serum expression of IL-1β or TGF-β in BE patients was analyzed. Finally, receiver operating characteristic (ROC) curves were generated to determine the diagnostic value of the cytokines.RESULTS:
IL-1β and TGF-β levels were higher in the serum of BE patients than those in non-BE patients, and the expression of either IL-1β or TGF-β showed a strong positive correlation with the serum expression of bilirubin in BE patients. Moreover, the results of ROC analysis showed that either IL-1β or TGF-β could distinguish BE patients from healthy controls.CONCLUSION:
IL-1β and TGF-β levels were upregulated in BE and might function as potential biomarkers or therapeutic targets for BE patients.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Cytokines
/
Kernicterus
Type of study:
Diagnostic study
Limits:
Child
/
Humans
/
Infant, Newborn
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2020
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Shanxi Provincial Childrens Hospital/CN
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