Resistance training improves the lipid profile, combat oxidative stress and inhibit MMP-2 activity in the left ventricle diet-induced obese rats
Motriz (Online)
;
26(3): e019919, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1143305
ABSTRACT
Abstract Aims:
The purpose of the present study was to evaluate the effects of the resistance training (RT) on the lipid profile and metabolism, oxidative stress, and activity of metalloproteinase-2 (MMP-2) in the left ventricle (LV) of diet-induced obesity rats.Methods:
Forty males Wistar rats 90 days-old were grouped into four groups (n=10) i) Sedentary group (SED); ii) Obese sedentary group, feed with high-fat diet (Ob-SED); iii) Resistance Trained group (RT), and iv) Obese Resistance trained group (Ob-RT). The LV was assayed to Obesity index, LV lipid content, citrate synthase activity, lipid peroxidation (TBARS), enzymatic and non-enzymatic antioxidant systems, lipid profile, cardio-metabolic parameters, and activity of MMP-2.Results:
High-fat diet was associated with manifestations of the obesity, body mass gain, and increased obesity index, accompanied by an alteration in the lipid profile. On the other hand, RT was able to prevent body weight gain, to reduce the obesity index and to improve the lipid profile, to elevate the activation of the citrate synthase, and to decrease MMP-2 activity in the LV of obese rats.Conclusion:
RT positively modulated blood lipid profile and antioxidant enzymes preventing the increased activity of MMP-2 in the left ventricle from rats fed with high-fat diet.
Full text:
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Index:
LILACS (Americas)
Main subject:
Exercise
/
Oxidative Stress
/
Lipid Metabolism
/
Diet, High-Fat
Limits:
Animals
Language:
English
Journal:
Motriz (Online)
Journal subject:
EducaÆo F¡sica e Treinamento
/
Medicina Esportiva
/
Medicina F¡sica e ReabilitaÆo
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Santa Catarina/BR
/
Universidade Federal de São Carlos/BR
/
Universidade Federal do Espírito Santo/BR
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