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Expression of annexin-A1 in blood and tissue leukocytes of leprosy patients
Ribeiro, Afonso Bezerra; Caloi, Caroline Marques; Pimenta, Silvia Thais Sá; Seshayyan, Sudha; Govindarajulu, Srinivas; Souto, Francisco José Dutra; Damazo, Amílcar Sabino.
  • Ribeiro, Afonso Bezerra; Universidade Federal de Mato Grosso. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Cuiabá. BR
  • Caloi, Caroline Marques; Universidade Federal de Mato Grosso. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Cuiabá. BR
  • Pimenta, Silvia Thais Sá; Universidade Federal de Mato Grosso. Faculdade de Medicina. Cuiabá. BR
  • Seshayyan, Sudha; The Tamil Nadu Dr. MGR Medical University. Guindy. IN
  • Govindarajulu, Srinivas; The Tamil Nadu Dr. MGR Medical University. Department of Epidemiology. Guindy. IN
  • Souto, Francisco José Dutra; Universidade Federal de Mato Grosso. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Cuiabá. BR
  • Damazo, Amílcar Sabino; Universidade Federal de Mato Grosso. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Cuiabá. BR
Rev. Soc. Bras. Med. Trop ; 53: e20200277, 2020. graf
Article in English | SES-SP, ColecionaSUS, LILACS | ID: biblio-1143873
ABSTRACT
Abstract INTRODUCTION In leprosy, immune system mediators that regulate the infectious process act in a complex manner and can lead to several clinical outcomes. To understand the behavior of these mediators we quantified the expression of annexin-A1 (ANXA1) in the peripheral blood and plasma as well as tissue leukocytes in all clinical forms of leprosy and compared with healthy controls. METHODS Seventy healthy controls and 70 patients with leprosy, tuberculoid (TT) (n = 13), borderline tuberculoid (BT) (n = 15), borderline borderline (BB) (n = 13), borderline lepromatous (BL) (n = 15), and lepromatous leprosy (LL) (n = 14), were selected. Phenotyping of the lymphocyte cells and the intracellular expression of ANXA1 in leukocytes was performed by immunofluorescence. Plasma protein levels were determined by enzyme-linked immunosorbent assay. RESULTS Histiocytes and CD4+ and CD8+ T cells in the skin of BL and LL patients had higher ANXA1 expression. ANXA1 expression was also high in circulating polymorphonuclear, monocytes, and CD4+ and CD8+ T cells in the blood of LL patients compared to those of TT, BT, BB, and BL patients, and these levels were similar to those in healthy controls. Plasma ANXA1 levels indicate an increase in paracrine release in patients with LL. CONCLUSIONS The data indicate that ANXA1 expression is enhanced in the leukocytes and plasma of patients with LL, and may contribute to the inhibition of leukocyte action, leading to inadequate functioning of the immune system and thus contributing to the spread of M. leprae infection.
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Full text: Available Index: LILACS (Americas) Main subject: Leprosy, Lepromatous / Annexin A1 / Leprosy Limits: Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Year: 2020 Type: Article Institution/Affiliation country: The Tamil Nadu Dr. MGR Medical University/IN / Universidade Federal de Mato Grosso/BR

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Full text: Available Index: LILACS (Americas) Main subject: Leprosy, Lepromatous / Annexin A1 / Leprosy Limits: Humans Language: English Journal: Rev. Soc. Bras. Med. Trop Year: 2020 Type: Article Institution/Affiliation country: The Tamil Nadu Dr. MGR Medical University/IN / Universidade Federal de Mato Grosso/BR