Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
Rev. Soc. Bras. Med. Trop
;
54: e01452020, 2021. tab, graf
Article
in English
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1143891
ABSTRACT
Abstract INTRODUCTION:
We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.METHODS:
This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.RESULTS:
A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.CONCLUSIONS:
This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Schistosomiasis
/
Mannose-Binding Lectin
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Animals
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Year:
2021
Type:
Article
Institution/Affiliation country:
Universidade Federal de Pernambuco/BR
/
Universidade de Pernambuco/BR
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