Impact of preoperative aspirin on long-term outcomes in diabetic patients following coronary artery bypass grafting: a propensity score matched study
Rev. bras. cir. cardiovasc
;
35(6): 859-868, Nov.-Dec. 2020. tab, graf
Article
in English
| LILACS, SES-SP
| ID: biblio-1144000
ABSTRACT
Abstract Introduction:
This study aimed to determine the effect of preoperative aspirin administration on early and long-term clinical outcomes in patients suffering from diabetes mellitus (DM) undergoing coronary artery bypass grafting (CABG).Methods:
In this observational study, a total of 315 patients were included and grouped according to the time interval between their last aspirin dose and the time of surgery; patients who had been continued aspirin intake with last administered dose ≤ 24-hours before CABG (n=144) and those who had been given the last dose of aspirin between 24 to 48 hours before CABG (n=171).Results:
Multivariable analysis showed that the continuation of preoperative aspirin intake ≤ 24 hours before CABG in patients with DM is associated with reduced incidence of 30-day major adverse cardiac and cerebral events (MACCE) (P=0.004) as well as reduced incidence of composite 30-day mortality/MACCE (P=0.012). During mean follow-up of 37±17.5 months, the unadjusted hazard ratio (HR) showed that aspirin ≤ 24 hours prior CABG in patients with DM significantly reduced the incidence of MACCE and composite of mortality/MACCE during follow-up (HR 0.50; 95% confidence interval [CI] 0.29-0.87; P=0.014 and HR 0.61; 95% CI 0.38-0.97; P=0.039, respectively). However, after propensity score (PS) matching, the PS-adjusted HR showed a non-significant trend towards the reduction of MACCE during follow-up (HR 0.58; 95% CI 0.31-1.06; P=0.081).Conclusion:
Continuation of preoperative aspirin intake ≤ 24 hours before CABG in patients with DM is associated with reduced incidence of early MACCE, but without significant influence on long-term outcomes.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Anti-Inflammatory Agents, Non-Steroidal
/
Aspirin
/
Coronary Artery Bypass
/
Diabetes Mellitus
/
Percutaneous Coronary Intervention
Type of study:
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Rev. bras. cir. cardiovasc
Year:
2020
Type:
Article
Institution/Affiliation country:
Medinet Heart Center Ltd/PL
/
Nottingham University Hospital/GB
/
Nowa Sol Multidisciplinary Hospital/PL
/
Sana-Heart Center Cottbus/DE
/
Universidade de Pernambuco/BR
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