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Evaluation of frequency of autoimmune hepatitis autoantibodies in children with type 1 diabetes / Frecuencia de anticuerpos de hepatitis autoinmune en niños con diabetes tipo I
Honar, Naser; Karamizadeh, Zohreh; Vazirian, Majid-Vares; Jahanshahi, Keramatallah; Manouchehri, Ali; Dehghani, Seyed Mohsen; Javaherizadeh, Hazhir.
  • Honar, Naser; Shiraz University of Medical Sciences. Shiraz. IR
  • Karamizadeh, Zohreh; Shiraz University of Medical Sciences. Shiraz. IR
  • Vazirian, Majid-Vares; Shiraz University of Medical Sciences. Shiraz. IR
  • Jahanshahi, Keramatallah; Shiraz University of Medical Sciences. Shiraz. IR
  • Manouchehri, Ali; Shiraz University of Medical Sciences. Shiraz. IR
  • Dehghani, Seyed Mohsen; Shiraz University of Medical Sciences. Shiraz. IR
  • Javaherizadeh, Hazhir; Ahvaz Jundishapur University of Medical Sciences. Ahvaz. IR
Rev. gastroenterol. Perú ; 39(4): 344-347, oct.-dic 2019. ilus, tab
Article in English | LILACS | ID: biblio-1144619
ABSTRACT

Background:

Diabetes mellitus type 1 (T1DM) is one of the childhood diseases with growing prevalence. Various accompanying autoimmune diseases were seen with type 1 diabetes. The most common autoimmune diseases with T1DM are autoimmune thyroiditis and celiac disease. In some reports, autoimmune hepatitis has been reported in association with DM-1.

Objectives:

The aim of this study was to evaluate autoimmune hepatitis autoantibodies in children with T1DM. Materials and

methods:

In this crosssectional study, 202 children with T1DM were evaluated (47.5% were males and 52.5% were girls). Liver enzymes, autoimmune hepatitis related autoantibodies such as anti-nuclear antibodies (ANA), anti-smooth muscle (ASMA) and anti liver and kidney microsomal antibodies (LKM-1) were measured. Liver ultrasound was done for participants and biopsy of liver was taken for children with increased echogenicity of the liver, hepatomegaly or elevated liver enzymes. Results analyzed by statistical software spss-16, Descriptive statistics and chi-square test, paired T-TEST. Level of less than 5% was considered statistically significant.

Results:

In 6 patients ANA and in 4 patients (2%) ASMA was positive,1 patient was ASMA positive but ANA negative. None of the patients were Anti LKM-1 positive. 3 patients had positive ANA and ASMA, and increased liver echogenicity on ultrasound simultaneously. Histological evaluation was showed that 2 patients had findings in favor of autoimmune hepatitis.

Conclusion:

Auto antibodies were positive in 10 cases. ANA was positive in 6 (2.97%) of all cases. ASMA was positive in 4 (1.98%) cases. Increased echogenicity was found in 3 cases. Histological evaluation showed 2 patients had biopsy confirmed autoimmune hepatitis. AIH-2 was not seen among our cases.
RESUMEN
Antecedentes La diabetes mellitus tipo 1 (DM1) es una de las enfermedades infantiles con mayor prevalencia. Se observaron varias enfermedades autoinmunes acompañantes con diabetes tipo 1. Las enfermedades autoinmunes más comunes con DM1 son la tiroiditis autoinmune y la enfermedad celíaca. En algunos reportes, se ha encontrado hepatitis autoinmune en asociación con DM-1.

Objetivos:

El objetivo de este estudio fue evaluar los autoanticuerpos de hepatitis autoinmunes en niños con DM1. Materiales y

métodos:

En este estudio transversal, se evaluaron 202 niños con DM1 (47,5% eran hombres y 52,5% eran niñas). Se midieron las enzimas hepáticas, los autoanticuerpos autoinmunes relacionados con la hepatitis, como los anticuerpos antinucleares (ANA), el músculo liso (ASMA) y los anticuerpos microsomales hepáticos y renales (LKM-1). Se realizó una ecografía hepática para los participantes y se tomó una biopsia del hígado para niños con mayor ecogenicidad del hígado, hepatomegalia o enzimas hepáticas elevadas. Los resultados fueron analizados por el software estadístico spss-16 usando estadística descriptiva y prueba de chi-cuadrado, T-TEST pareado. Se consideró estadísticamente significativo un nivel menor del 5%.

Resultados:

En 6 pacientes con ANA y en 4 pacientes (2%) ASMA fue positiva, 1 paciente fue ASMA positiva pero ANA negativa. Ninguno de los pacientes fue anti LKM-1 positivo. 3 pacientes tuvieron ANA y ASMA positivas, y aumentaron la ecogenicidad hepática en la ecografía simultáneamente. La evaluación histológica mostró que 2 pacientes tenían hallazgos a favor de la hepatitis autoinmune.

Conclusión:

Los autoanticuerpos fueron positivos en 10 casos. ANA fue positivo en 6 (2,97%) de todos los casos. La ASMA fue positiva en 4 (1,98%) casos. Se encontró mayor ecogenicidad en 3 casos. La evaluación histológica mostró que 2 pacientes tenían biopsia confirmada de hepatitis autoinmune. AIH-2 no fue visto entre nuestros casos.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Autoantibodies / Hepatitis, Autoimmune / Diabetes Mellitus, Type 1 Type of study: Observational study / Prevalence study / Risk factors Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Rev. gastroenterol. Perú Journal subject: Gastroenterology Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Ahvaz Jundishapur University of Medical Sciences/IR / Shiraz University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Autoantibodies / Hepatitis, Autoimmune / Diabetes Mellitus, Type 1 Type of study: Observational study / Prevalence study / Risk factors Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Rev. gastroenterol. Perú Journal subject: Gastroenterology Year: 2019 Type: Article Affiliation country: Iran Institution/Affiliation country: Ahvaz Jundishapur University of Medical Sciences/IR / Shiraz University of Medical Sciences/IR