Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy
Acta cir. bras
;
36(2): e360204, 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1152699
ABSTRACT
ABSTRACT Purpose To present a model to reproduce the clinical condition, in order to better understand the pathophysiology of neurological impairment related to intoxication. Methods Twenty-five Wistar rats were used and divided into five groups Shaw group (WHI), water gavage group (WGV), star fruit gavage group (SGV), nephropathic group with water gavage (NPW), nephropathic group with star fruit gavage (NPS).Nephropathic groups were submitted to surgery, developing nephropathy. After surgery, they received preestablished gavage with star fruit juice or water. The electroencephalographic records were evaluated in the experimental nephropathic group that received gavage of star fruit juice. Results To assess the induction of neurotoxicity using electroencephalographic data, the NPS group demonstrated the presence of epileptic seizures associated with star fruit intoxication. Conclusions The experimental model herein presented was adequate to reproduce the clinical condition experienced by nephropathic patients who ingest star fruit juice, establishing, thus, an experimental model utterly important for the study of the neurological toxicity process.
Full text:
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Index:
LILACS (Americas)
Main subject:
Fruit
/
Kidney Diseases
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2021
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto de Assistência Médica ao Servidor Público Estadual/BR
/
Universidade Católica de São Paulo/BR
/
Universidade Cidade de São Paulo/BR
/
Universidade São Judas Tadeu/BR
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