Chronic osteo-articular changes in patients with sickle cell disease
Adv Rheumatol
;
61: 11, 2021. tab
Article
in English
| LILACS
| ID: biblio-1152745
ABSTRACT
Abstract Background:
Sickle cell disease (SCD) is an autosomal recessive genetic disease in which a mutation occurs in the β-globin chain gene, resulting in abnormal hemoglobin levels. In an environment with reduced oxygen concentration, red blood cells change their conformation, resulting in chronic hemolysis and consequent anemia and vaso-occlusive crises with injuries to several organs, with a significant impairment of the osteoarticular system. This study aimed to verify the chronic osteoarticular alterations and their association with clinical and laboratory characteristics of patients with SCD with a more severe phenotype (SS and Sβ0), on a steady-state fasis.Methods:
Fifty-five patients were referred to a medical consultation with a specialized assessment of the locomotor system, followed by laboratory tests and radiographic examinations.Results:
In total, 74.5% patients had hemoglobinopathy SS; 67.3% were female; and 78.2% were non-whites. The mean patient age was 30.5 years. Most patients (61.8%) reported up to three crises per year, with a predominance of high-intensity pain (65.5%). Radiographic alterations were present in 80% patients. A total of 140 lesions were identified, most which were located in the spine, femur, and shoulders. Most lesions were osteonecrosis and osteoarthritis and were statistically associated with the non-use of hydroxyurea.Conclusions:
There was a high prevalence of chronic osteoarticular alterations, which was statistically associated only with the non-regular use of hydroxyurea.(AU)
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Osteoarthritis
/
Osteonecrosis
/
Bone Diseases, Metabolic
/
Hydroxyurea
/
Anemia, Sickle Cell
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Adv Rheumatol
Journal subject:
Artrite
/
Reumatologia
Year:
2021
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University Triângulo Mineiro/BR
/
Federal University of Triângulo Mineiro/BR
Similar
MEDLINE
...
LILACS
LIS