Associations between serum calcium, 25(OH)D level and bone mineral density in adolescents
Adv Rheumatol
;
61: 16, 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1152746
ABSTRACT
Abstract Backgrounds It is important to improve our understanding of the roles of calcium and vitamin D in bone health for preventing osteoporosis. We aimed at exploring the associations between serum calcium, vitamin D level, and bone mineral density (BMD) in adolescents included in the National Health and Nutrition Examination Survey (NHANES) 2001 - 2006. Methods:
Weighted multivariate linear regression models were used to estimate the associations of serum calcium, 25(OH)D level with total BMD. Smooth curve fitting was used to explore the potential non-linear relationship.Results:
A total of 5990 individuals aged between 12 and 19 years were included in this study. The fully-adjusted model showed serum calcium positively correlated with total BMD. However, an inverted U-shaped relationship was found when we performed the smooth curve fitting method, and the inflection point was calculated at 9.6 mg/dL using the two-piecewise linear regression model. In contrast, there was a positive correlation between serum 25(OH)D and total BMD after adjusting for potential confounders.Conclusions:
The present study revealed a positive correlation between serum 25(OH)D level and total BMD, and an inverted U-shaped relationship between serum calcium and total BMD.(AU)
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vitamin D
/
Bone Density
/
Calcium
Type of study:
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Humans
Language:
English
Journal:
Adv Rheumatol
Journal subject:
Artrite
/
Reumatologia
Year:
2021
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Xiaoshan Affiliated Hospital of Wenzhou Medical University/CN
/
Zhejiang Xiaoshan Hospital/CN
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