Acute liver failure due to radiographically occult infiltration of urothelial cancer
Autops. Case Rep
;
11: e2021256, 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1153179
ABSTRACT
Introduction Acute liver failure (ALF) due to diffuse infiltrating solid malignancy without any focal lesions on radiographic imaging is rare. Case report A 70-year-old man was admitted due to mental confusion, abdominal pain, and ALF. Three years before, he had undergone a left nephrectomy for urothelial carcinoma followed by adjuvant chemotherapy. The abdominal computed tomography (CT) showed hepatomegaly and ascites. Ascitic fluid had transudate characteristics, with no malignant cells. Percutaneous liver biopsy (LB) showed diffuse liver infiltration of metastatic urothelial carcinoma. The patient rapidly deteriorated and died in a week due to ALF. Discussion History of solid cancer and hepatomegaly and/or liver failure without other obvious explanation should encourage to perform LB. Conclusion LB is warranted to avoid misdiagnosis, prolonged hospital stays, and delay in palliative care.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Urinary Bladder Neoplasms
/
Carcinoma
/
Liver Failure, Acute
Type of study:
Diagnostic study
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Autops. Case Rep
Journal subject:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Year:
2021
Type:
Article
Affiliation country:
Italy
/
Portugal
Institution/Affiliation country:
Centro Hospitalar Universitário de Lisboa Central/PT
/
University Hospital Città della Salute e della Scienza di Torino/IT
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