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Multicomponent physical activity program to prevent body changes and metabolic disturbances associated with antiretroviral therapy and improve quality of life of people living with HIV: a pragmatic trial
Santos, Elisabete Cristina Morandi dos; Florindo, Alex Antonio; Santos, Ardiles Vitor; Picone, Camila de Melo; Dias, Túlio Gamio; Segurado, Aluisio Cotrim.
  • Santos, Elisabete Cristina Morandi dos; Universidade de São Paulo. Divisao/Departamento de Molestias Infecciosas e Parasitarias. Sao Paulo. BR
  • Florindo, Alex Antonio; Universidade de São Paulo. Escola de Ciencias, Artes e Humanidades. Sao Paulo. BR
  • Santos, Ardiles Vitor; Universidade de São Paulo. Divisao/Departamento de Molestias Infecciosas e Parasitarias. Sao Paulo. BR
  • Picone, Camila de Melo; Universidade de São Paulo. Divisao/Departamento de Molestias Infecciosas e Parasitarias. Sao Paulo. BR
  • Dias, Túlio Gamio; Prefeitura Municipal de Joinville. Joinville. BR
  • Segurado, Aluisio Cotrim; Universidade de São Paulo. Divisao/Departamento de Molestias Infecciosas e Parasitarias. Sao Paulo. BR
Clinics ; 76: e2457, 2021. tab, graf
Article in English | LILACS | ID: biblio-1153938
ABSTRACT

OBJECTIVES:

Comprehensive care for people living with human immunodeficiency virus (HIV) (PLH) includes the promotion of healthier habits, including physical activity (PA). This study aimed to describe a multicomponent pragmatic trial protocol to assess the effect of PA in preventing body changes and metabolic disturbances, improving the quality of life of PLH starting antiretroviral therapy (ART) and present cohort characteristics.

METHODS:

PLH undergoing ART for ≤4 months were recruited for a randomized trial. The intervention comprised three cardiorespiratory and/or strength training sessions per week at the clinic or in public spaces for 6 months under on-site or remote supervision, and educational sessions. Participants' PA levels, cardiorespiratory fitness, anthropometric measures, strength, flexibility, quality of life, and laboratory monitoring (blood glucose and lipids, CD4 counts) at baseline and post-intervention will be compared. The pragmatic design aims to enable the assessment of intervention effectiveness in real-life conditions.

RESULTS:

At baseline, our cohort of 38 recently diagnosed patients (mean time since HIV diagnosis and duration of ART were 3 and 2.58 months, respectively) were predominantly male, young, with high schooling and good immune status (median CD4 count=498 cells/mm3). Twenty-two (57.9%) patients reported a PA below the World Health Organization recommendations. We found baseline normal anthropometric measures and metabolic parameters below-average trunk flexion and elbow extension strength, poor handgrip strength and flexibility, and high quality of life scores in all except the physical domain.

CONCLUSIONS:

Understanding how effective PA is in preventing body changes and metabolic disturbances, and in improving the quality of PLH starting ART may help establish guidelines to better incorporate PA in HIV care.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Quality of Life / HIV Infections Type of study: Controlled clinical trial / Practice guideline / Risk factors Limits: Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Prefeitura Municipal de Joinville/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Quality of Life / HIV Infections Type of study: Controlled clinical trial / Practice guideline / Risk factors Limits: Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Prefeitura Municipal de Joinville/BR / Universidade de São Paulo/BR