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Microablative fractional radiofrequency as a therapeutic option for vulvar lichen sclerosus: a pilot study
Kamilos, Márcia Farina; Aguiar, Lana Maria; Batista, Valéria Holmo; Roa, Cristiane Lima; Aguiar, Fernando Nalesso; Soares Júnior, José Maria; Baracat, Edmund Chada.
  • Kamilos, Márcia Farina; Universidade de São Paulo. Departamento de Obstetricia e Ginecologia. Sao Paulo. BR
  • Aguiar, Lana Maria; Universidade de São Paulo. Departamento de Obstetricia e Ginecologia. Sao Paulo. BR
  • Batista, Valéria Holmo; Universidade de São Paulo. Departamento de Obstetricia e Ginecologia. Sao Paulo. BR
  • Roa, Cristiane Lima; Universidade de São Paulo. Departamento de Obstetricia e Ginecologia. Sao Paulo. BR
  • Aguiar, Fernando Nalesso; Universidade de São Paulo. Instituto do Cancer do Estado de Sao Paulo (ICESP). Patologia. Sao Paulo. BR
  • Soares Júnior, José Maria; Universidade de São Paulo. Departamento de Obstetricia e Ginecologia. Sao Paulo. BR
  • Baracat, Edmund Chada; Universidade de São Paulo. Departamento de Obstetricia e Ginecologia. Sao Paulo. BR
Clinics ; 76: e2567, 2021. graf
Article in English | LILACS | ID: biblio-1153942
ABSTRACT

OBJECTIVES:

To assess the clinical response to and the histomorphometric effects of microablative fractional radiofrequency (MFR) in women with symptomatic vulvar lichen sclerosus (VLS).

METHODS:

This was a pilot study on the use of MFR for the treatment of VLS. Upon recruitment and at each treatment session, all participants were examined and each of their symptoms were rated on a visual analog scale. After the procedure, the participants completed a satisfaction questionnaire. We compared the morphometric findings of vulvar biopsies performed at enrollment and after the last treatment session. The participants were divided into three groups according to previous treatment with corticosteroids G1, no previous treatment; G2, treated for up to 5 years; and G3, treated for >5 years.

RESULTS:

This study included 26 women. After two to three sessions, most participants in all groups became either "asymptomatic" or "much better" than before treatment and were "very satisfied" or "satisfied" with the intervention. Pruritus and burning sensation were the most frequently reported symptoms. Nearly 40% of the participants in all groups reported complete remission of symptoms. The improvement was rated as moderate or higher by 80%, 76%, and 66% of the women in groups 1, 2, and 3, respectively. The improvement of symptoms persisted for 11 months (range, 7-16 months), on average, after the treatment. Type III collagen concentration significantly increased and was associated with important symptom improvement. Tissue trophism and vascularization also increased but did not reach statistical significance, probably because of the small number of cases.

CONCLUSIONS:

MFR may be an effective and safe treatment for symptomatic VLS.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Lichen Sclerosus et Atrophicus / Vulvar Lichen Sclerosus Limits: Female / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Lichen Sclerosus et Atrophicus / Vulvar Lichen Sclerosus Limits: Female / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR