Autologous blood salvage in cardiac surgery: clinical evaluation, efficacy and levels of residual heparin
Hematol., Transfus. Cell Ther. (Impr.)
;
43(1): 1-8, Jan.-Mar. 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1154297
ABSTRACT
ABSTRACT Objective:
Intraoperative blood salvage (cell saver technique) in cardiac surgery is universally used in surgical procedures with a marked risk of blood loss. The primary objectives of this study were to determine the concentration of residual heparin in the final product that is reinfused into the patient in the operating room and to evaluate the efficacy and safety of the cell saver technique.Method:
Twelve patients undergoing elective cardiac surgery were enrolled in this study. Using the XTRA Autotransfusion System, blood samples were collected from the cardiotomy reservoir, both prior to blood processing (pre-sample) and after it, directly from the bag with processed product (post-sample). Hematocrit and hemoglobin levels, the protein, albumin and residual heparin concentrations, hemolysis index, and the platelet, erythrocyte and leukocyte counts were measured.Results:
Hematocrit and hemoglobin levels and red blood cell counts were higher in post-processing samples, with a mean variation of 54.78%, 19.81 g/dl and 6.84 × 106/mm3, respectively (p < 0.001). The mean hematocrit of the processed bag was 63.49 g/dl (range 57.2-67.5). The residual heparin levels were ≤0.1 IU/ml in all post-treatment analyses (p = 0.003). No related adverse events were observed.Conclusion:
The reduced residual heparin values (≤0.1 IU/ml) in processed blood found in this study are extremely important, as they are consistent with the American Association of Blood Banks guidelines, which establish target values below 0.5 IU/ml. The procedure was effective, safe and compliant with legal requirements and the available international literature.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Blood Transfusion, Autologous
/
Heparin
/
Operative Blood Salvage
Type of study:
Practice guideline
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Hematol., Transfus. Cell Ther. (Impr.)
Journal subject:
Hematologia
/
TransfusÆo de Sangue
Year:
2021
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Banco de Sangue de São Paulo/BR
/
Hospital do Coração da Assoc/BR
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