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High-resolution CT pulmonary findings in children with severe asthma
Silva, Thiago Krieger Bento da; Zanon, Matheus; Altmayer, Stephan; Pacini, Gabriel Sartori; Watte, Guilherme; Stein, Renato; Pitrez, Paulo Márcio; Hochhegger, Bruno.
  • Silva, Thiago Krieger Bento da; Pontifícia Universidade Católica do Rio Grande do Sul. Postgraduate Program in Pediatrics. Rio Grande do Sul. BR
  • Zanon, Matheus; Universidade Federal de Ciências da Saúde de Porto Alegre. Department of Radiology. Rio Grande do Sul. BR
  • Altmayer, Stephan; Universidade Federal de Ciências da Saúde de Porto Alegre. Department of Radiology. Rio Grande do Sul. BR
  • Pacini, Gabriel Sartori; Universidade Federal de Ciências da Saúde de Porto Alegre. Department of Radiology. Rio Grande do Sul. BR
  • Watte, Guilherme; Pontifícia Universidade Católica do Rio Grande do Sul. Postgraduate Program in Medicine and Health Sciences. Rio Grande do Sul. BR
  • Stein, Renato; Pontifícia Universidade Católica do Rio Grande do Sul. Postgraduate Program in Pediatrics. Rio Grande do Sul. BR
  • Pitrez, Paulo Márcio; Pontifícia Universidade Católica do Rio Grande do Sul. Postgraduate Program in Pediatrics. Rio Grande do Sul. BR
  • Hochhegger, Bruno; Pontifícia Universidade Católica do Rio Grande do Sul. Postgraduate Program in Pediatrics. Rio Grande do Sul. BR
J. pediatr. (Rio J.) ; 97(1): 37-43, Jan.-Feb. 2021. tab, graf
Article in English | LILACS | ID: biblio-1154715
ABSTRACT
Abstract

Objective:

To compare quantitative CT parameters between children with severe asthma and healthy subjects, correlating to their clinical features.

Methods:

We retrospectively analyzed CT data from 19 school-aged children (5-17 years) with severe asthma and 19 control school-aged children with pectus excavatum. The following CT parameters were evaluated total lung volume (TLV), mean lung density (MLD), CT air trapping index (AT%) (attenuation ≤856 HU), airway wall thickness (AWT), and percentage of airway wall thickness (AWT%). Multi-detector computed tomography (MDCT) data were correlated to the following clinical parameters forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), forced expiratory flow at 25-75% (FEF 25-75%), FEV1/FVC ratio, sputum and bronchoalveolar lavage analysis, serum IgE levels, and previous hospitalizations due to asthma.

Results:

Asthma patients presented higher mean values of AT% (23.8 ± 6.7% vs. controls, 9.7 ± 3.2%), AWT (1.46 ± 0.22 mm vs. controls, 0.47 ± −735 ± 28 HU vs. controls, −666 ± 19 HU). Mean AT% was 29.0 ± 4.7% in subjects with previous hospitalization against 19.2 ± 5.0% in those with no prior hospitalization (p < 0.001). AT% presented very strong negative correlations with FVC (r = −0.933, p < 0.001) and FEV1 (r = −0.841, p < 0.001) and a moderate correlation with FEF 25-75% (r = −0.608, p = 0.007). AT% correlation with FEV1/FVC ratio and serum IgE was weak (r = −0.184, p = 0.452, and r = −0.363, p = 0.202)

Conclusion:

Children with severe asthma present differences in quantitative chest CT scans compared to healthy controls with strong correlations with pulmonary function tests and previous hospitalizations due to asthma.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Asthma Type of study: Diagnostic study / Observational study Limits: Adolescent / Aged / Child / Child, preschool / Humans Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Pontifícia Universidade Católica do Rio Grande do Sul/BR / Universidade Federal de Ciências da Saúde de Porto Alegre/BR

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Full text: Available Index: LILACS (Americas) Main subject: Asthma Type of study: Diagnostic study / Observational study Limits: Adolescent / Aged / Child / Child, preschool / Humans Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Pontifícia Universidade Católica do Rio Grande do Sul/BR / Universidade Federal de Ciências da Saúde de Porto Alegre/BR