Zika virus RNA excretion in sweat with concomitant detection in other body fluid specimens
Mem. Inst. Oswaldo Cruz
;
115: e200339, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1154865
ABSTRACT
We evaluated sweat, blood and urine specimens obtained from an ongoing cohort study in Brazil. Samples were collected at pre-established intervals after the initial rash presentation and tested for Zika virus (ZIKV) RNA presence by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). From 254 participants with confirmed infection, ZIKV RNA was detected in the sweat of 46 individuals (18.1%). Sweat presented a median cycle threshold (Ct) of 34.74 [interquartile range (IQR) 33.44-36.04], comparable to plasma (Ct 35.96 - IQR 33.29-36.69) and higher than urine (Ct 30.78 - IQR 28.72-33.22). Concomitant detection with other specimens was observed in 33 (72%) of 46 participants who had a positive result in sweat. These findings represent an unusual and not yet investigated virus shedding through eccrine glands.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Sweat
/
RNA, Viral
/
Zika Virus
/
Zika Virus Infection
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2020
Type:
Article
Affiliation country:
Brazil
/
Switzerland
/
United States
Institution/Affiliation country:
Fundação Oswaldo Cruz-Fiocruz/BR
/
Fundação de Medicina Tropical Doutor Heitor Vieira Dourado/BR
/
Henry M Jackson Foundation for the Advancement of Military Medicine/US
/
Instituto Nacional de Infectologia Evandro Chagas/BR
/
Ministério da Saúde/BR
/
Organização Mundial da Saúde+BR
/
Universidade do Estado do Amazonas/BR
/
Walter Reed Army Institute of Research/US
/
World Health Organization/CH
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