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Spatiotemporal multiple insecticide resistance in Aedes aegypti populations in French Guiana: need for alternative vector control
Guidez, Amandine; Pocquet, Nicolas; Restrepo, Johana; Mathieu, Luana; Gaborit, Pascal; Issaly, Jean; Carinci, Romuald; Chandre, Fabrice; Epelboin, Yanouk; Romain, Girod; Dusfour, Isabelle.
  • Guidez, Amandine; Institut Pasteur de la Guyane. Cayenne. GF
  • Pocquet, Nicolas; Université de Montpellier. Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle. Institut de Recherche pour le Développement. Montpellier. FR
  • Restrepo, Johana; Institut Pasteur de la Guyane. Cayenne. GF
  • Mathieu, Luana; Institut Pasteur de la Guyane. Cayenne. GF
  • Gaborit, Pascal; Institut Pasteur de la Guyane. Cayenne. GF
  • Issaly, Jean; Institut Pasteur de la Guyane. Cayenne. GF
  • Carinci, Romuald; Institut Pasteur de la Guyane. Cayenne. GF
  • Chandre, Fabrice; Université de Montpellier. Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle. Institut de Recherche pour le Développement. Montpellier. FR
  • Epelboin, Yanouk; Institut Pasteur de la Guyane. Cayenne. GF
  • Romain, Girod; Institut Pasteur de la Guyane. Cayenne. GF
  • Dusfour, Isabelle; Institut Pasteur de la Guyane. Cayenne. GF
Mem. Inst. Oswaldo Cruz ; 115: e200313, 2020. tab, graf
Article in English | LILACS | ID: biblio-1154867
Responsible library: BR1.1
ABSTRACT
BACKGROUND Aedes aegypti is the sole vector of urban arboviruses in French Guiana. Overtime, the species has been responsible for the transmission of viruses during yellow fever, dengue, chikungunya and Zika outbreaks. Decades of vector control have produced resistant populations to deltamethrin, the sole molecule available to control adult mosquitoes in this French Territory. OBJECTIVES Our surveillance aimed to provide public health authorities with data on insecticide resistance in Ae. aegypti populations and other species of interest in French Guiana. Monitoring resistance to the insecticide used for vector control and to other molecule is a key component to develop an insecticide resistance management plan. METHODS In 2009, we started to monitor resistance phenotypes to deltamethrin and target-site mechanisms in Ae. aegypti populations across the territory using the WHO impregnated paper test and allelic discrimination assay. FINDINGS Eight years surveillance revealed well-installed resistance and the dramatic increase of alleles on the sodium voltage-gated gene, known to confer resistance to pyrethroids (PY). In addition, we observed that populations were resistant to malathion (organophosphorous, OP) and alpha-cypermethrin (PY). Some resistance was also detected to molecules from the carbamate family. Finally, those populations somehow recovered susceptibility against fenitrothion (OP). In addition, other species distributed in urban areas revealed to be also resistant to pyrethroids. CONCLUSION The resistance level can jeopardize the efficiency of chemical adult control in absence of other alternatives and conducts to strongly rely on larval control measures to reduce mosquito burden. Vector control strategies need to evolve to maintain or regain efficacy during epidemics.
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Full text: Available Index: LILACS (Americas) Main subject: Pyrethrins / Insecticide Resistance / Aedes / Mosquito Vectors / Insecticides Limits: Animals Country/Region as subject: South America / English Caribbean / Guyana / French Guiana Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2020 Type: Article Affiliation country: France / French Guiana Institution/Affiliation country: Institut Pasteur de la Guyane/GF / Université de Montpellier/FR

Full text: Available Index: LILACS (Americas) Main subject: Pyrethrins / Insecticide Resistance / Aedes / Mosquito Vectors / Insecticides Limits: Animals Country/Region as subject: South America / English Caribbean / Guyana / French Guiana Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2020 Type: Article Affiliation country: France / French Guiana Institution/Affiliation country: Institut Pasteur de la Guyane/GF / Université de Montpellier/FR