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Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019
Chun, Zeng Mei; Jun, Jia Qing.
  • Chun, Zeng Mei; Zhejiang University. College of Medicine. The First Affiliated Hospital. Hangzhou. CN
  • Jun, Jia Qing; Hangzhou Center for Disease Control and Prevention. Department of TB Control and Prevention. Hangzhou. CN
Rev. Soc. Bras. Med. Trop ; 54: e0728-2020, 2021. tab, graf
Article in English | LILACS | ID: biblio-1155535
Responsible library: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.

METHODS:

MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.

RESULTS:

Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V).

CONCLUSIONS:

The proportion of mono-SM-resistant TB among new patients was higher.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pharmaceutical Preparations / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Limits: Humans Country/Region as subject: Asia Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Hangzhou Center for Disease Control and Prevention/CN / Zhejiang University/CN

Full text: Available Index: LILACS (Americas) Main subject: Pharmaceutical Preparations / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Limits: Humans Country/Region as subject: Asia Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Hangzhou Center for Disease Control and Prevention/CN / Zhejiang University/CN