Alta frecuencia de DQ8 en la población celiaca de la provincia del Chaco, Argentina / [High frequency of DQ8 in the celiac population of Chaco province, Argentina].
Acta gastroenterol. latinoam
;
44(1): 16-21, 2014 Mar.
Article
in Spanish
| LILACS, BINACIS
| ID: biblio-1157429
ABSTRACT
BACKGROUND:
There is a strong association between celiac disease (CD) and certain genes of the major histocompatibility complex (HLA). The CD specifically related alleles are those coding for HLA-DQ2 heterodimer and to a lesser degree for HLA-DQ8. OBJECTVE. The aim of this study was to evaluate the frequency of HLA-DQB1* and HLA-DRB1* alleles, haplotypes, and genotypes in patients diagnosed with CD and in control population of Chaco, in order to establish its distribution and compare it with that observed in other populations.METHODS:
A total of 139 samples from patients diagnosed with CD and 119 healthy controls were typed for HLA-DQ and HLA-DR, using PCR and reverse hybridization (INNO-LiPA or Dynal).RESULTS:
Comparing patients with CD vs. controls, the DQBI*0201 (P = 0.0002), DQBJ*0202 (P = 0.0046), DQBI*0302 (P = 0. 0006), DRBl *03 (P = 0.0002), DRBl *04 (P = 0.0199) and DRB1 *07 (P = 0.0062) were significantly increased, while a decrease was observed in HLA-DQB1*0301 (P = 0.0006), HLA-DQBI*0303 (P = 0.0070), DQBI*0501 (P = 0.0023), DQB1*0604 (P = 0.0140) DRB1*01 (P = 0.0023), DRB1*08 (P = 0.0165), DRB1*09 (P = 0.0362) and DRB1*16 (P = 0.0228). Within DQB1* genotypes associated with EC, 65.4
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Index:
LILACS (Americas)
Main subject:
HLA-DQ Antigens
/
Celiac Disease
/
Genetic Predisposition to Disease
/
HLA-DRB1 Chains
Type of study:
Observational study
/
Risk factors
Country/Region as subject:
South America
/
Argentina
Language:
Spanish
Journal:
Acta gastroenterol. latinoam
Journal subject:
Gastroenterology
Year:
2014
Type:
Article
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