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Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology
López de Cicco, R; Bassi, D E; Page, R; Klein-Szanto, A J.
  • López de Cicco, R; s.af
  • Bassi, D E; s.af
  • Page, R; s.af
  • Klein-Szanto, A J; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA, USA..
Acta odontol. latinoam ; 15(1-2): 29-37, 2002.
Article in Spanish | LILACS-Express | LILACS, BINACIS | ID: biblio-1157645
ABSTRACT
Furin is a proprotein convertase that activates many cancer development-related substrates such as growth factors, growth factor-receptors, adhesion molecules, and matrix degrading enzymes. Furin expression was studied in sections from tissue microarrays (TMA) and conventional paraffin blocks in a collection of squamous cell carcinomas (SCC) from three different sites. A total of 118 SCCs from the oral cavity, lung and esophagus as well as 34 precursor lesions (intraepithelial neoplasia) from the oral and bronchial mucosae were studied by immunohistochemistry. Furin expression was notably higher in most precursor lesions than in normal epithelia. Tumors from either the TMAs or the conventional blocks showed significant differences when compared to the mostly negative normal epithelia. High levels of furin expression were observed in approximately 50
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Index: LILACS (Americas) Language: Spanish Journal: Acta odontol. latinoam Journal subject: Dentistry Year: 2002 Type: Article

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Index: LILACS (Americas) Language: Spanish Journal: Acta odontol. latinoam Journal subject: Dentistry Year: 2002 Type: Article