The C677T thermolabile variant of methylene tetrahydrofolate reductase on homocysteine, folate and vitamin B12 in a hemodialysis center
Medicina (B.Aires)
;
62(2): 149-153, 2002.
Article
in Spanish
| LILACS, BINACIS
| ID: biblio-1165113
ABSTRACT
Homocysteine is a risk factor for cardiovascular disease. Mutations in a key enzyme in homocysteine metabolism, methylenetetrahydrofolate reductase, may contribute to hyperhomocysteinemia and alter folate and cobalamin levels. After starting hemodialysis, 10 mg oral folate daily and 500 micrograms intravenous methylcobalamin once weekly were prescribed to 27 hemodialysis patients (time on hemodialysis > or = 12 months) and two groups were defined: Group A normal; Group B heterozygous. Initial, third and twelfth month measurements of homocysteine, serum folate and vitamin B12 levels were collected and analyzed. Heterozygous state of methylenetetrahydrofolate reductase prevalence was 48
Search on Google
Index:
LILACS (Americas)
Main subject:
Vitamin B 12
/
Folic Acid
/
Oxidoreductases Acting on CH-NH Group Donors
/
Homocysteine
/
Kidney Failure, Chronic
Type of study:
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Medicina (B.Aires)
Journal subject:
Medicine
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS