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Toxicity evaluation of water extract of tissue-cultured Taraxacum formosanum by acute, subacute administration, and Ames test
Tsai, Wen-Che; Chang, Hung-Chi; Tseng, Yi-Han; Yin, Hsin-Yi; Liao, Jiunn-Wang; Chandra Agrawal, Dinesh; Wen, Hsiao-Wei.
  • Tsai, Wen-Che; National Chung Hsing University. Department of Food Science and Biotechnology. Taichung. TW
  • Chang, Hung-Chi; Chaoyang University of Technology. Department of Golden-Ager Industry Management. Taichung. TW
  • Tseng, Yi-Han; National Chung Hsing University. Department of Food Science and Biotechnology. Taichung. TW
  • Yin, Hsin-Yi; National Chung Hsing University. Department of Food Science and Biotechnology. Taichung. TW
  • Liao, Jiunn-Wang; National Chung Hsing University. Institute of Veterinary Pathology. Taichung. TW
  • Chandra Agrawal, Dinesh; Chaoyang University of Technology. Department of Applied Chemistry. Taichung. TW
  • Wen, Hsiao-Wei; National Chung Hsing University. Department of Food Science and Biotechnology. Taichung. TW
Electron. j. biotechnol ; 45: 38-45, May 15, 2020. ilus, graf, tab
Article in English | LILACS | ID: biblio-1177420
Responsible library: CL1.1
ABSTRACT

BACKGROUND:

Taraxacum species (commonly known as dandelion) used as herbal medicine have been reported to exhibit an antiproliferative effect on hepatoma cells and antitumor activity in non-small-cell lung cancer cells. Although several investigations have demonstrated the safety of Taraxacum officinale, the safety of tissue-cultured plants of T. formosanum has not been assessed so far. Therefore, the present study examines the safety of the water extract of the entire plant of tissue cultured T. formosanum based on acute and subacute toxicity tests in rats, as well as the Ames tests.

RESULTS:

No death or toxicity symptoms were observed in the acute and subacute tests. The results of the acute test revealed that the LD50 (50% of lethal dose) value of the T. formosanum water extract for rats exceeded 5 g/kg bw. No abnormal changes in the body weight, weekly food consumption, organ weight, or hematological, biochemical, and morphological parameters were observed in the subacute toxicity test. Thus, the no observed adverse effect level (NOAEL) of T. formosanum water extract was estimated to be higher than 2.0 g/kg. Finally, the results of the Ames test revealed that T. formosanum water extract was not genotoxic at any tested concentration to any of five Salmonella strains.

CONCLUSIONS:

The water extract of tissue-cultured T. formosanum was non-toxic to rats in acute and subacute tests and exhibited no genotoxicity to five Salmonella strains.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Taraxacum / Tissue Culture Techniques Limits: Animals Language: English Journal: Electron. j. biotechnol Journal subject: Biotechnology Year: 2020 Type: Article Affiliation country: Taiwan Institution/Affiliation country: Chaoyang University of Technology/TW / National Chung Hsing University/TW

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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Taraxacum / Tissue Culture Techniques Limits: Animals Language: English Journal: Electron. j. biotechnol Journal subject: Biotechnology Year: 2020 Type: Article Affiliation country: Taiwan Institution/Affiliation country: Chaoyang University of Technology/TW / National Chung Hsing University/TW