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Hemophagocytic lymphohistiocytosis presenting as acute coronary syndrome
Melki, Gabriel; Alkomos, Mina Fransawy; Nanavati, Sushant; Kumar, Vinod; Mariyam, Christina; Maroules, Michael.
  • Melki, Gabriel; St. Josephs University Medical Center. Internal Medicine Department. Paterson. US
  • Alkomos, Mina Fransawy; St. Josephs University Medical Center. Internal Medicine Department. Paterson. US
  • Nanavati, Sushant; St. Josephs University Medical Center. Pulmonary and Critical Care Department. Paterson. US
  • Kumar, Vinod; St. Josephs University Medical Center. Hematology and Oncology Department. Paterson. US
  • Mariyam, Christina; St. Josephs University Medical Center. Internal Medicine Department. Paterson. US
  • Maroules, Michael; St. Josephs University Medical Center. Hematology and Oncology Department. Paterson. US
Autops. Case Rep ; 11: e2021285, 2021. graf
Article in English | LILACS | ID: biblio-1249016
ABSTRACT
Acquired Hemophagocytic Lymphohistiocytosis is a rare and deadly syndrome resulting from an overactive immune system, with uncontrolled activation of macrophages and lymphocytes, hypercytokinemia, and systemic inflammatory response. A 75-year-old male presented with typical anginal pain and was diagnosed with the acute coronary syndrome, which required a percutaneous transluminal coronary angioplasty. Instead of resolving the symptoms, the patient began to exhibit pyrexia and worsening altered sensorium with progressing renal failure, anemia, thrombocytopenia and respiratory failure. This constellation of symptoms caused the patient to require mechanical ventilation and hemodialysis. Upon laboratory analysis, hyperferritinemia provided an indication to the diagnosis of acquired hemophagocytic lymphohistiocytosis. After the initiation of dexamethasone, the patient made a significant recovery and was discharged from the hospital.
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Full text: Available Index: LILACS (Americas) Main subject: Lymphohistiocytosis, Hemophagocytic / Hyperferritinemia Limits: Aged / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: United States Institution/Affiliation country: St. Josephs University Medical Center/US

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Full text: Available Index: LILACS (Americas) Main subject: Lymphohistiocytosis, Hemophagocytic / Hyperferritinemia Limits: Aged / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: United States Institution/Affiliation country: St. Josephs University Medical Center/US