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Economic model for obtaining cyclodextrins from commercial cgtase
Koga, Luciana Numata; Fenelon, Vanderson Carvalho; Miyoshi, Juliana Harumi; Moriwaki, Cristiane; Wessel, Kamila Byanca Baldin; Mangolim, Camila Sampaio; Matioli, Graciette.
  • Koga, Luciana Numata; State University of Maringá. Department of Pharmacy. Maringá. BR
  • Fenelon, Vanderson Carvalho; State University of Maringá. Department of Pharmacy. Maringá. BR
  • Miyoshi, Juliana Harumi; State University of Maringá. Department of Pharmacy. Maringá. BR
  • Moriwaki, Cristiane; State University of Maringá. Department of Pharmacy. Maringá. BR
  • Wessel, Kamila Byanca Baldin; State University of Londrina. Londrina. BR
  • Mangolim, Camila Sampaio; Federal University of Paraíba. Department of Management and Industrial Technology. BR
  • Matioli, Graciette; State University of Maringá. Department of Pharmacy. Maringá. BR
Braz. J. Pharm. Sci. (Online) ; 56: e18993, 2020. graf
Article in English | LILACS | ID: biblio-1249146
ABSTRACT
A repetitive batch process was employed followed by membrane ultrafiltration system to produce low-cost cyclodextrins (CDs) using commercial enzymes Toruzyme® cyclomaltodextrin glucanotransferase (CGTase) and its kinetic parameters were determined. The ultrafiltration system enabled the removalof inhibitory products from the reaction medium, allowing the enzyme to be recovered for reuse. A 10 kDa membrane was used to separate the different CDs produced by the CGTase. The substrates evaluated were maltodextrin, corn starch and cassava starch at 5, 10 and 15% (w/V), in the presence and absence of 10% (V/V) ethanol. After reaction for 132 h, 10% (w/V) cassava starch in the presence of ethanol provided the best results with 32.1 mg/mL of ß-CD. Maximum production occurred after 72 h of reaction, with a yield of 87.4% of ß-CD and an α-CD, ß-CD and γ-CD production ratio of 110.08 g, respectively. When eight repetitive batches of 72 h followed by ultrafiltration and crystallization of ß-CD were performed, 2.1 g of precipitate was obtained with a purity of 67.6% ß-CD. The supernatant from the crystallization process was lyophilized and resulted in 35.3% α-CD. The developed model can be used industrially for the production of low cost CDs from easily obtained raw

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Full text: Available Index: LILACS (Americas) Main subject: Ultrafiltration / Models, Economic / Low Cost Technology / Cyclodextrins / Starch and Fecula Type of study: Health economic evaluation Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraíba/BR / State University of Londrina/BR / State University of Maringá/BR

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Full text: Available Index: LILACS (Americas) Main subject: Ultrafiltration / Models, Economic / Low Cost Technology / Cyclodextrins / Starch and Fecula Type of study: Health economic evaluation Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraíba/BR / State University of Londrina/BR / State University of Maringá/BR