Clinical and epidemiological aspects of Candidemia in eight medical centers in the state of Parana, Brazil: Parana Candidemia Network
Braz. j. infect. dis
;
25(1): 101041, jan., 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1249290
ABSTRACT
ABSTRACT Objectives:
Candida spp. has been reported as one of the common agents of nosocomial bloodstream infections and is associated with a high mortality. Therefore, this study evaluated the clinical findings, local epidemiology, and microbiological aspects of candidemia in eight tertiary medical centers in the state of Parana, South of Brazil.Methods:
In this study, we reported 100 episodes of candidemia in patients admitted to eight different hospitals in five cities of the state of Parana, Brazil, using data collected locally (2016 and 2017) and tabulated online.Results:
The incidence was found to be 2.7 / 1000 patients / day and 1.2 / 1000 admissions. C. albicans was responsible for 49% of all candidemia episodes. Cancer and surgery were the two most common underlying conditions associated with candidemia. The mortality rate within 30 days was 48%, and removal of the central venous catheter (p = 0.029) as well as empirical or prophylactic exposure to antifungals were both related to improved survival (p = 0.033).Conclusions:
This study highlights the high burden and mortality rates of candidemia in hospitals from Parana as well as the need to enhance antifungal stewardship program in the enrolled medical centers.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Cross Infection
/
Incidence
/
Candidemia
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2021
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital Erasto Gaertner/BR
/
Hospital Santa Casa de Maringá/BR
/
Hospital Universitário Regional Norte/BR
/
Hospital Universitário do Oeste do Paraná/BR
/
Hospital Universitário dos Campos Gerais/BR
/
Hospital do Câncer UOPECCAN/BR
/
Hospital do Câncer de Londrina/BR
/
Universidade Federal de São Paulo/BR
/
Universidade Federal do Paraná/BR
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