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Role of cancer ratio and other new parameters in the differential diagnosis of malignant pleural effusion
Ren, Zenghua; Xu, Ling.
  • Ren, Zenghua; Shanghai Jiao Tong University Affiliated Sixth Peoples Hospital. Department of Respiratory Medicine. CN
  • Xu, Ling; Shanghai Jiao Tong University Affiliated Sixth Peoples Hospital. Department of Respiratory Medicine. CN
Clinics ; 76: e2515, 2021. tab
Article in English | LILACS | ID: biblio-1249577
ABSTRACT

OBJECTIVES:

We compared the diagnostic potential of cancer ratio (CR, serum lactate dehydrogenase [LDH]/pleural fluid adenosine deaminase [pfADA]), cancer ratio plus (CR plus, cancer ratio/pleural lymphocyte percentage), and age/pfADA ratio with pfADA in malignant pleural effusion.

METHODS:

Data from 100 patients with malignant pleural effusion (MPE) and 119 patients with tuberculous pleural effusion (TPE) were retrospectively collected. PfADA, age/pfADA ratio, CR, and CR plus were compared between patients with MPE and those with TPE in two age groups (≤50 and >50 years). The best cut-off value was determined, and the diagnostic performance was evaluated according to the receiver operating characteristic curve.

RESULTS:

PfADA was statistically significantly lower while age/pfADA ratio, CR, and CR plus were significantly higher in the MPE group than in the TPE group in both age groups (p<0.05). For patients aged ≤50 years, the differential diagnostic value of pfADA for MPE was better than those of age/pfADA ratio, CR, and CR plus. At a cut-off value of 13.0 U/L, the sensitivity, specificity, and accuracy were 88.9%, 100.0%, and 98.9%, respectively. For patients aged >50 years, the diagnostic performance of CR plus was superior to those of pfADA, age/pfADA ratio, and CR. At a cut-off value of 22.6, the sensitivity, specificity, and accuracy of CR plus for the diagnosis of MPE were 86.8%, 84.6%, and 86.2%, respectively.

CONCLUSIONS:

The best parameter for diagnosing MPE was different for patients aged ≤50 years and >50 years. For patients aged >50 years, CR plus was a good parameter for the differential diagnosis of MPE. For patients aged ≤50 years, pfADA was better.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pleural Effusion / Pleural Effusion, Malignant Type of study: Diagnostic study / Observational study Limits: Child, preschool / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Shanghai Jiao Tong University Affiliated Sixth Peoples Hospital/CN

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Full text: Available Index: LILACS (Americas) Main subject: Pleural Effusion / Pleural Effusion, Malignant Type of study: Diagnostic study / Observational study Limits: Child, preschool / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Shanghai Jiao Tong University Affiliated Sixth Peoples Hospital/CN