Your browser doesn't support javascript.
loading
Effect of coinfection with influenza virus and bacteria on host damage / Efecto de la coinfección por virus de la influenza y bacterias en el daño al hospedero
Castro, Ana María; Cabello-Gutiérrez, Carlos; Pulido-Camarillo, Evelyn; García-García, Alexis E; Pérez-Torres, Armando.
  • Castro, Ana María; Universidad Nacional Autónoma de México. Faculty of Medicine. Department of Public Health. Mexico City. MX
  • Cabello-Gutiérrez, Carlos; Instituto Nacional de Enfermedades Respiratorias. Laboratory of Virology. Mexico City. MX
  • Pulido-Camarillo, Evelyn; Universidad Nacional Autónoma de México. Faculty of Medicine. Department of Cell and Tissue Biology. Mexico City. MX
  • García-García, Alexis E; Universidad Nacional Autónoma de México. Faculty of Medicine. Department of Public Health. Mexico City. MX
  • Pérez-Torres, Armando; Universidad Nacional Autónoma de México. Faculty of Medicine. Department of Cell and Tissue Biology. Mexico City. MX
Gac. méd. Méx ; 156(4): 270-275, Jul.-Aug. 2020. graf
Article in English | LILACS | ID: biblio-1249910
ABSTRACT
Abstract

Background:

Influenza virus infection is often complicated by a bacterial infection, with this coinfection causing severe pneumonia. If not timely treated, the disease can cause death.

Objective:

To demonstrate, in animal models, that coinfection with influenza virus and bacteria that affect the respiratory tract causes multisystemic damage.

Method:

Six groups of mice were formed a control group, one infected with the influenza virus, two infected with bacteria Haemophilus influenzae and Streptococcus pneumoniae, respectively; and two co-infected with influenza virus and Haemophilus influenzae or Streptococcus pneumoniae, respectively.

Results:

Of the six groups of mice, only the group co-infected with influenza virus and Streptococcus pneumoniae showed damage to thoracic and abdominal organs. A decrease in serum cytokine levels was found in all study groups, which was more pronounced in the co-infected mice.

Conclusions:

The groups of mice infected with Streptococcus pneumoniae or influenza virus alone showed no damage, which indicates that coexistence of these infections caused the damage in the group of co-infected mice.
RESUMEN
Resumen Antecedentes La infección por el virus de la influenza con frecuencia se complica con una infección bacteriana, coinfección que provoca cuadros graves de neumonía, la cual puede ocasionar la muerte si no es tratada en forma oportuna.

Objetivo:

Demostrar en modelos animales que la coinfección por el virus de la influenza y bacterias que afectan el tracto respiratorio ocasiona daño multisistémico.

Método:

Se formaron seis grupos de ratones un grupo control, uno infectado de virus de la influenza, dos infectados de bacterias Haemophilus influenzae y Streptococcus pneumoniae, respectivamente; y dos coinfectados de virus de la influenza y Haemophilus influenzae y Streptococcus pneumoniae, respectivamente.

Resultados:

De los seis grupos de ratones, solo en el grupo coinfectado de virus de la influenza y Streptococcus pneumoniae se observó daño en órganos torácicos y abdominales. En todos los grupos se encontró disminución de los niveles séricos de las citocinas, mayor en los ratones coinfectados.

Conclusiones:

Los grupos de ratones infectados solo de Streptococcus pneumoniae o el virus de la influenza no presentaron daños, lo cual indica que la coexistencia de estas infecciones fue la que ocasionó el daño en el grupo de ratones coinfectados.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pneumococcal Infections / Orthomyxoviridae Infections / Haemophilus Infections Limits: Animals Language: English Journal: Gac. méd. Méx Journal subject: Medicine Year: 2020 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Nacional de Enfermedades Respiratorias/MX / Universidad Nacional Autónoma de México/MX

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Pneumococcal Infections / Orthomyxoviridae Infections / Haemophilus Infections Limits: Animals Language: English Journal: Gac. méd. Méx Journal subject: Medicine Year: 2020 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Nacional de Enfermedades Respiratorias/MX / Universidad Nacional Autónoma de México/MX