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Immune system: development and acquisition of immunological competence
Moraes-Pinto, Maria Isabel de; Suano-Souza, Fabíola; Aranda, Carolina S.
  • Moraes-Pinto, Maria Isabel de; Universidade Federal de São Paulo. Departamento de Pediatria. São Paulo. BR
  • Suano-Souza, Fabíola; Universidade Federal de São Paulo. Departamento de Pediatria. São Paulo. BR
  • Aranda, Carolina S; Universidade Federal de São Paulo. Departamento de Pediatria. São Paulo. BR
J. pediatr. (Rio J.) ; 97(supl.1): 59-66, Mar.-Apr. 2021. graf
Article in English | LILACS | ID: biblio-1250232
ABSTRACT
Abstract

Objectives:

To describe the ontogeny of the immune system and the adaptive mechanisms of the immune system in the neonatal period, with an emphasis on transplacental antibody transport and breastfeeding. Source of data Non-systematic literature review in the PubMed database. Summary of the

findings:

The last two decades have witnessed a great advance in the knowledge of the immune system since conception. Several investigation tools have provided insight on phenomena that were previously inadequately understood. Still expanding, the functional and molecular investigation of various aspects of the immune system will make it possible to understand how intra-uterus maternal-fetal exchanges, the maternal microbiota interacting with the fetus and newborn, and the acquisition of immunological competence occur in healthy and disease scenarios.

Conclusions:

In-depth knowledge of the development of the immune system and of the adaptive mechanisms that allow a safer transition to the extrauterine environment are fundamental components of optimizing maternal and young infant vaccination, as well as the strategies associated with full postnatal development, and the early diagnosis and treatment of innate errors of immunity.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Microbiota / Immune System Type of study: Screening study Limits: Female / Humans / Infant / Infant, Newborn / Pregnancy Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Microbiota / Immune System Type of study: Screening study Limits: Female / Humans / Infant / Infant, Newborn / Pregnancy Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR