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The branched-chain amino acid transaminase 1 -23c/g polymorphism confers protection against acute coronary syndrome
Ramírez-Bello, Julian; Vargas-Alarcón, Gilberto; Pérez-Méndez, Óscar; Martínez-Ríos, Marco A.; Peña-Duque, Marco A.; Cardoso-Saldaña, Guillermo; Posadas-Romero, Carlos; Sierra-Martínez, Mónica; Fragoso, José M..
  • Ramírez-Bello, Julian; Hospital Juárez de México. Research Unit. Mexico City. MX
  • Vargas-Alarcón, Gilberto; Instituto Nacional de Cardiología Ignacio Chávez. Department of Molecular Biology. Mexico City. MX
  • Pérez-Méndez, Óscar; Instituto Nacional de Cardiología Ignacio Chávez. Department of Molecular Biology. Mexico City. MX
  • Martínez-Ríos, Marco A.; Instituto Nacional de Cardiología Ignacio Chávez. Department of Interventional Cardiology. Mexico City. MX
  • Peña-Duque, Marco A.; Instituto Nacional de Cardiología Ignacio Chávez. Department of Interventional Cardiology. Mexico City. MX
  • Cardoso-Saldaña, Guillermo; Instituto Nacional de Cardiología Ignacio Chávez. Department of Endocrinology. Mexico City. MX
  • Posadas-Romero, Carlos; Instituto Nacional de Cardiología Ignacio Chávez. Department of Endocrinology. Mexico City. MX
  • Sierra-Martínez, Mónica; Hospital Juárez de México. Department of Laboratory of Genetics and Molecular Diagnosis. Mexico City. MX
  • Fragoso, José M.; Instituto Nacional de Cardiología Ignacio Chávez. Department of Molecular Biology. Mexico City. MX
Rev. invest. clín ; 72(1): 19-24, Jan.-Feb. 2020. tab
Article in English | LILACS | ID: biblio-1251830
ABSTRACT
ABSTRACT

Background:

Previous studies have shown an association between polymorphisms of the BAT1-NF-κB inhibitor-like-1 (NFKBIL1)-LTA genomic region and susceptibility to myocardial infarction and acute coronary syndrome (ACS).

Objective:

The objective of the study was to study the role of three polymorphisms in the BAT1, NFKBIL1, and LTA genes on the susceptibility or protection against ACS; we included a group of cases-controls from Central Mexico.

Methods:

The BAT1 rs2239527C/G, NFKBIL1 rs2071592T/A, and LTA rs1800683G/A polymorphisms were genotyped using a 5' TaqMan assay in a group of 625 patients with ACS and 617 healthy controls.

Results:

Under a recessive model, the BAT1 -23C/G (rs2239527) polymorphism showed an association with protection against ACS (odds ratio = 0.56, and p-corrected = 0.019). In contrast, the genotype and allele frequencies of the NFKBIL1 rs2071592T/A and LTA rs1800683G/A polymorphisms were similar between ACS patients and controls and no association was identified.

Conclusion:

Our data suggest an association between the BAT1 -23C/G polymorphism and protection against ACS in Mexican patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: DEAD-box RNA Helicases / Acute Coronary Syndrome / Myocardial Infarction Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: Mexico Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2020 Type: Article Affiliation country: Mexico Institution/Affiliation country: Hospital Juárez de México/MX / Instituto Nacional de Cardiología Ignacio Chávez/MX

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Full text: Available Index: LILACS (Americas) Main subject: DEAD-box RNA Helicases / Acute Coronary Syndrome / Myocardial Infarction Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: Mexico Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2020 Type: Article Affiliation country: Mexico Institution/Affiliation country: Hospital Juárez de México/MX / Instituto Nacional de Cardiología Ignacio Chávez/MX