The branched-chain amino acid transaminase 1 -23c/g polymorphism confers protection against acute coronary syndrome
Rev. invest. clín
;
72(1): 19-24, Jan.-Feb. 2020. tab
Article
in English
| LILACS
| ID: biblio-1251830
ABSTRACT
ABSTRACT Background:
Previous studies have shown an association between polymorphisms of the BAT1-NF-κB inhibitor-like-1 (NFKBIL1)-LTA genomic region and susceptibility to myocardial infarction and acute coronary syndrome (ACS).Objective:
The objective of the study was to study the role of three polymorphisms in the BAT1, NFKBIL1, and LTA genes on the susceptibility or protection against ACS; we included a group of cases-controls from Central Mexico.Methods:
The BAT1 rs2239527C/G, NFKBIL1 rs2071592T/A, and LTA rs1800683G/A polymorphisms were genotyped using a 5' TaqMan assay in a group of 625 patients with ACS and 617 healthy controls.Results:
Under a recessive model, the BAT1 -23C/G (rs2239527) polymorphism showed an association with protection against ACS (odds ratio = 0.56, and p-corrected = 0.019). In contrast, the genotype and allele frequencies of the NFKBIL1 rs2071592T/A and LTA rs1800683G/A polymorphisms were similar between ACS patients and controls and no association was identified.Conclusion:
Our data suggest an association between the BAT1 -23C/G polymorphism and protection against ACS in Mexican patients.
Full text:
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Index:
LILACS (Americas)
Main subject:
DEAD-box RNA Helicases
/
Acute Coronary Syndrome
/
Myocardial Infarction
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Mexico
Language:
English
Journal:
Rev. invest. clín
Journal subject:
Medicine
Year:
2020
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Hospital Juárez de México/MX
/
Instituto Nacional de Cardiología Ignacio Chávez/MX
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