A novel prognostic index in patients with resectable esophageal squamous cell carcinoma: fibrinogen/prealbumin ratio
Rev. invest. clín
;
72(1): 46-54, Jan.-Feb. 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1251834
ABSTRACT
ABSTRACT Background:
Fibrinogen (Fib) to albumin (ALB) fibrinogen-to-albumin ratio as a prognostic index for esophageal cancer has been confirmed. A novel prognostic index was initially proposed with fibrinogen to prealbumin ratio (FPR) in patients with resectable esophageal squamous cell carcinoma (ESCC).Objective:
The objective of the study was to study the prognostic role of the novel prognostic index (FPR) in patients with resectable ESCC without any neoadjuvant treatment.Methods:
In this retrospective study, a total of 372 resectable ESCC patients without any neoadjuvant treatment were included. The best cutoff values were selected by the receiver operating characteristic curves. Two Cox regression analyses with forward stepwise (one for categorical variables and the other for continuous variables) were used to evaluate the overall survival (OS) and cancer-specific survival (CSS).Results:
The best cutoff point was 0.014 for FPR. Patients with lower levels of FPR (≤0.014) had better CSS (50.7% vs. 18.0%, p < 0.001) and OS (48.0% vs. 17.6%, p < 0.001) than patients with higher levels of FPR (> 0.014). Multivariate Cox analyses (categorical and continuous) demonstrated that FPR was an independent prognostic factor in CSS (categorical hazard ratio [HR] 2.014, 95% confidence interval [CI] 1.504-2.697, p < 0.001; continuous per 0.01 HR 1.438, 95% CI 1.154-1.793, p = 0.001) and OS (categorical HR 1.964, 95% CI 1.475-2.617, p < 0.001; continuous per 0.01 HR 1.429, 95% CI 1.146-1.781, p = 0.002).Conclusions:
Our study indicated that FPR served as an independent prognostic factor in patients with resectable ESCC.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Fibrinogen
/
Prealbumin
/
Esophageal Neoplasms
/
Esophageal Squamous Cell Carcinoma
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. invest. clín
Journal subject:
Medicine
Year:
2020
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
University of the Chinese Academy of Sciences/CN
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