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Impact of comorbidities in mexican SARS-COV-2-positive patients: a retrospective analysis in a national cohort
Kammar-García, Ashuin; Vidal-Mayo, José de J.; Vera-Zertuche, Juan M.; Lazcano-Hernández, Martín; Vera-López, Obdulia; Segura-Badilla, Orietta; Aguilar-Alonso, Patricia; Navarro-Cruz, Addi R..
  • Kammar-García, Ashuin; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Emergency Department. Mexico City. MX
  • Vidal-Mayo, José de J.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Emergency Department. Mexico City. MX
  • Vera-Zertuche, Juan M.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Endocrinology. Obesity Clinic. Mexico City. MX
  • Lazcano-Hernández, Martín; Benemérita Universidad Autónoma de Puebla. Faculty of Chemical Sciences. Deparment of Biochemistry and Foods. Pue. MX
  • Vera-López, Obdulia; Benemérita Universidad Autónoma de Puebla. Faculty of Chemical Sciences. Deparment of Biochemistry and Foods. Pue. MX
  • Segura-Badilla, Orietta; Universidad del Bío-Bío. Faculty of Health and Food Sciences. Department of Nutrition and Public Health. Concepción. CL
  • Aguilar-Alonso, Patricia; Benemérita Universidad Autónoma de Puebla. Faculty of Chemical Sciences. Deparment of Biochemistry and Foods. Pue. MX
  • Navarro-Cruz, Addi R.; Benemérita Universidad Autónoma de Puebla. Faculty of Chemical Sciences. Deparment of Biochemistry and Foods. Pue. MX
Rev. invest. clín ; 72(3): 151-158, May.-Jun. 2020. tab, graf
Article in English | LILACS | ID: biblio-1251849
ABSTRACT
ABSTRACT

Background:

The coronavirus disease 2019 outbreak is a significant challenge for health-care systems around the world.

Objective:

The objective of the study was to assess the impact of comorbidities on the case fatality rate (CFR) and the development of adverse events in patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Mexican population. Materials and

methods:

We analyzed the data from 13,842 laboratory-confirmed SARS-CoV-2 patients in Mexico between January 1, 2020, and April 25, 2020. We investigated the risk of death and the development of adverse events (hospitalization, pneumonia, orotracheal intubation, and intensive care unit [ICU] admission), comparing the number of comorbidities of each patient.

Results:

The patient mean age was 46.6 ± 15.6 years, 42.3% (n = 5853) of the cases were women, 38.8% of patients were hospitalized, 4.4% were intubated, 29.6% developed pneumonia, and 4.4% had critical illness. The CFR was 9.4%. The risk of hospitalization (odds ratio [OR] = 3.1, 95% confidence interval [CI] 2.7-3.7), pneumonia (OR = 3.02, 95% CI 2.6-3.5), ICU admission (OR = 2, 95% CI 1.5-2.7), and CFR (hazard ratio = 3.5, 95% CI 2.9-4.2) was higher in patients with three or more comorbidities than in patients with 1, 2, or with no comorbidities.

Conclusions:

The number of comorbidities may be a determining factor in the clinical course and its outcomes in SARS-CoV-2-positive patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Pregnancy Country/Region as subject: Mexico Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2020 Type: Article Affiliation country: Chile / Mexico Institution/Affiliation country: Benemérita Universidad Autónoma de Puebla/MX / Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX / Universidad del Bío-Bío/CL

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Full text: Available Index: LILACS (Americas) Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Pregnancy Country/Region as subject: Mexico Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2020 Type: Article Affiliation country: Chile / Mexico Institution/Affiliation country: Benemérita Universidad Autónoma de Puebla/MX / Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX / Universidad del Bío-Bío/CL