Molecular markers for the diagnosis of high-risk human papillomavirus infection and triage of human papillomavirus-positive women
Rev. invest. clín
;
72(4): 198-212, Jul.-Aug. 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1251857
ABSTRACT
ABSTRACT Infection with high-risk human papillomavirus (HPV) increases the likelihood of developing cervical cancer (CC). A plethora of cellular processes is required to produce pre-malignant lesions, which in turn may become malignant if left untreated. Those changes are induced by viral oncoproteins, which represent an ideal target to identify the viral presence, or by some particularities of the host that ultimately promote the establishment of CC. This article describes the different methods used for HPV detection and quantification, as well as the current trend of secondary screening approaches to detect premalignant lesions and CC. In addition, we analyzed validated biomarkers and those under clinical investigation for the classification (triage) of women at risk of developing CC after an initial positive HPV test and that could be used as prognostic biomarkers for CC. The use of molecular biomarkers, together with the detection of HPV DNA sequences, provides a high impact diagnostic and prognostic tool in the detection of patients at increased risk of developing CC and also may guide their clinical management. In addition, some of those biomarkers could represent pharmacological targets for the future design of therapeutic approaches to CC treatment.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Uterine Cervical Neoplasms
/
Papillomavirus Infections
/
Alphapapillomavirus
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
Language:
English
Journal:
Rev. invest. clín
Journal subject:
Medicine
Year:
2020
Type:
Article
Affiliation country:
Denmark
/
Mexico
Institution/Affiliation country:
Instituto Mexicano del Seguro Social/MX
/
Instituto Nacional de Cancerología/MX
/
Instituto Nacional de Salud Pública/MX
/
Universidad Nacional Autónoma de México/MX
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