18f-Fluorodeoxyglucose Positron Emission Tomography Versus Bone Marrow Biopsy for the Evaluation of Bone Marrow Infiltration in Newly Diagnosed Lymphoma Patients
Rev. invest. clín
;
73(2): 79-86, Mar.-Apr. 2021. tab
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1251867
ABSTRACT
ABSTRACT Background:
Bone marrow evaluation (BME) is crucial for establishing an accurate staging and prognosis in lymphoma patients.Objective:
The objective of the study was to study the diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) against bone marrow biopsy (BMB) for BME.Methods:
Five hundred patient files of newly diagnosed lymphoma patients treated at an academic medical center were reviewed for BME at diagnosis by BMB and FDG PET-CT. Diagnostic performance of FDG PET-CT for detecting bone marrow infiltration (BMI) was assessed, as well as clinical predictors for positive BMB and positive FDG PET-CT.Results:
BMB was positive in 16.3% of all patients, and 28.7% had a positive FDG PET-CT for BMI. Overall, the sensitivity of FDG PET-CT was 74.1% and specificity 80.1%. As for predictors for BMB and FDG PET-CT positivity, B symptoms and thrombocytopenia were independent factors for BMI. Seventy-four patients had discordant results between BMB and FDG PET-CT, non-Hodgkin lymphoma (NHL) having the most significant discordance. This discrepancy did not affect treatment.Conclusions:
FDG PET-CT shows excellent performance for the detection of BMI in Hodgkin lymphoma. For diffuse large B-cell lymphoma, we recommend performing BMB and FDG PET-CT as complementary tests. In all other NHL, a unilateral BMB is mandatory at diagnosis.
Full text:
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Index:
LILACS (Americas)
Type of study:
Diagnostic study
/
Prognostic study
Language:
English
Journal:
Rev. invest. clín
Journal subject:
Medicine
Year:
2021
Type:
Article
Affiliation country:
Algeria
/
Mexico
Institution/Affiliation country:
Instituto Nacional de Cancerología/MX
/
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX
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