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18f-Fluorodeoxyglucose Positron Emission Tomography Versus Bone Marrow Biopsy for the Evaluation of Bone Marrow Infiltration in Newly Diagnosed Lymphoma Patients
Aguado-Vázquez, Tania M.; Olivas-Martínez, Antonio; Cancino-Ramos, Uvi; Zúüiga-Tamayo, Diego A.; Lome-Maldonado, María del C. A.; Rivas-Vera, Silvia; García-Pérez, Francisco O.; Candelaria-Hernández, Myrna G..
  • Aguado-Vázquez, Tania M.; Instituto Nacional de Cancerología. Department of Hematology. Mexico City. MX
  • Olivas-Martínez, Antonio; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Division of Medicine. Mexico City. MX
  • Cancino-Ramos, Uvi; Instituto Nacional de Cancerología. Department of Nuclear Medicine. Mexico City. MX
  • Zúüiga-Tamayo, Diego A.; Instituto Nacional de Cancerología. Department of Hematopathology. Mexico City. MX
  • Lome-Maldonado, María del C. A.; Instituto Nacional de Cancerología. Department of Hematopathology. Mexico City. MX
  • Rivas-Vera, Silvia; Instituto Nacional de Cancerología. Department of Hematology. Mexico City. MX
  • García-Pérez, Francisco O.; Instituto Nacional de Cancerología. Department of Nuclear Medicine. Mexico City. MX
  • Candelaria-Hernández, Myrna G.; Instituto Nacional de Cancerología. Department of Research Division. Mexico City. MX
Rev. invest. clín ; 73(2): 79-86, Mar.-Apr. 2021. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1251867
ABSTRACT
ABSTRACT

Background:

Bone marrow evaluation (BME) is crucial for establishing an accurate staging and prognosis in lymphoma patients.

Objective:

The objective of the study was to study the diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) against bone marrow biopsy (BMB) for BME.

Methods:

Five hundred patient files of newly diagnosed lymphoma patients treated at an academic medical center were reviewed for BME at diagnosis by BMB and FDG PET-CT. Diagnostic performance of FDG PET-CT for detecting bone marrow infiltration (BMI) was assessed, as well as clinical predictors for positive BMB and positive FDG PET-CT.

Results:

BMB was positive in 16.3% of all patients, and 28.7% had a positive FDG PET-CT for BMI. Overall, the sensitivity of FDG PET-CT was 74.1% and specificity 80.1%. As for predictors for BMB and FDG PET-CT positivity, B symptoms and thrombocytopenia were independent factors for BMI. Seventy-four patients had discordant results between BMB and FDG PET-CT, non-Hodgkin lymphoma (NHL) having the most significant discordance. This discrepancy did not affect treatment.

Conclusions:

FDG PET-CT shows excellent performance for the detection of BMI in Hodgkin lymphoma. For diffuse large B-cell lymphoma, we recommend performing BMB and FDG PET-CT as complementary tests. In all other NHL, a unilateral BMB is mandatory at diagnosis.


Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study / Prognostic study Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Algeria / Mexico Institution/Affiliation country: Instituto Nacional de Cancerología/MX / Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX

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Full text: Available Index: LILACS (Americas) Type of study: Diagnostic study / Prognostic study Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Algeria / Mexico Institution/Affiliation country: Instituto Nacional de Cancerología/MX / Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX