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Subgingival microbial profile of women with breast cancer: a cross-sectional study
Bernhard, Vivian Rodrigues; Faveri, Marcelo; Santos, Marciel Silva; Gomes, Maria da Conceição Machado; Batitucci, Roberta Grasseli; Tanaka, Caio Junji; Feres, Magda; Feitosa, Alfredo.
  • Bernhard, Vivian Rodrigues; Espirito Santo Federal University. Department of Dental Clinic. Postgraduate Program in Dental Clinic/PPGCO. Vitória. BR
  • Faveri, Marcelo; Guarulhos University. Dental Research Division. Department of Periodontology. Guarulhos. BR
  • Santos, Marciel Silva; Espirito Santo Federal University. Department of Dental Clinic. Postgraduate Program in Dental Clinic/PPGCO. Vitória. BR
  • Gomes, Maria da Conceição Machado; Espirito Santo Federal University. Department of Dental Clinic. Postgraduate Program in Dental Clinic/PPGCO. Vitória. BR
  • Batitucci, Roberta Grasseli; Espirito Santo Federal University. Department of Dental Clinic. Postgraduate Program in Dental Clinic/PPGCO. Vitória. BR
  • Tanaka, Caio Junji; Guarulhos University. Dental Research Division. Department of Periodontology. Guarulhos. BR
  • Feres, Magda; Guarulhos University. Dental Research Division. Department of Periodontology. Guarulhos. BR
  • Feitosa, Alfredo; Espirito Santo Federal University. Department of Dental Clinic. Postgraduate Program in Dental Clinic/PPGCO. Vitória. BR
Appl. cancer res ; 39: 1-7, 2019. tab, ilus, graf
Article in English | LILACS, Inca | ID: biblio-1254278
ABSTRACT

Background:

Some prospective studies have observed associations between periodontal disease and breast cancer. Therefore, the aim of the present study was to investigate the composition of the subgingival biofilm of women diagnosed with breast cancer, who also presented with chronic periodontitis.

Methods:

All subjects underwent clinical and microbiological assessment. Subgingival biofilm samples were taken from at least three sites of 44 women who had breast cancer. The mean levels and proportions of 40 bacterial species were determined by checkerboard DNA-DNA hybridization. Spearman correlation was used to assess possible associations between the mean levels of bacterial species and clinical conditions.

Results:

The five species found at the highest levels were Prevotella nigrescens, Actinomyces gerencseriae, Neisseria mucosa, Porphyromonas gingivalis and Tannerella forsythia. The species detected in the lowest counts were Propionibacterium acnes, Streptococcus constellatus, Streptococcus intermedius, Eubacterium saburreum and Streptococcus anginosus. No significant association between levels and proportion of bacterial species and clinical parameters were found.

Conclusion:

In conclusion, the results of the present study found no direct association between the subgingival microbiota and breast cancer and an indirect pathway should be addressed in further studies.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Chronic Periodontitis Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans Language: English Journal: Appl. cancer res Journal subject: Neoplasms Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Espirito Santo Federal University/BR / Guarulhos University/BR

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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Chronic Periodontitis Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans Language: English Journal: Appl. cancer res Journal subject: Neoplasms Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Espirito Santo Federal University/BR / Guarulhos University/BR