Influence of rs6667202 SNP on Interleukin-10 levels in the gingival fluid of patients with periodontitis grade C
Braz. j. oral sci
;
20: e211654, jan.-dez. 2021. ilus
Article
in English
| BBO, LILACS
| ID: biblio-1254524
ABSTRACT
Grade C periodontitis in youngers is characterized by a severe form of periodontitis, and IL10 rs6667202 single nucleotide polymorphism (SNP) has been described as an important feature in this disease etiology. Aim:
This study aimed to evaluate, in vivo, the functionality of IL10 rs6667202 SNP on IL-10 gingival fluid levels.Methods:
Thirty patients with Perio4C were selected, 15 with the IL10 AA genotype (rs6667202) and 15 with AC/CC genotypes. The gingival fluid was collected from two sites with probing depth ≥ 7 mm and bleeding on probing, and two healthy sites. The IL-10 concentration was determined by Luminex/MAGpix platform.Results:
In deep pockets, the IL10 AA genotype presented a lower concentration of IL-10 when compared with AC or CC genotypes (p<0.05). In shallow pockets, no difference between groups was seen (p>0.05).Conclusion:
IL10 rs6667202 SNP decreases the production of IL-10 in crevicular fluid, potentially affecting this disease progression
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Aggressive Periodontitis
/
Interleukin-10
/
Polymorphism, Single Nucleotide
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. oral sci
Journal subject:
Dentistry
Year:
2021
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of Campinas/BR
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