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Influence of rs6667202 SNP on Interleukin-10 levels in the gingival fluid of patients with periodontitis grade C
Stolf, Camila Schmidt; Taiete, Tiago; Casati, Márcio Zaffalon; Sallum, Enílson Antônio; Nociti Júnior, Francisco Humberto; Silvério, Karina Gonzales; Casarin, Renato Corrêa Viana.
  • Stolf, Camila Schmidt; University of Campinas. Piracicaba Dental School. Department of Prosthodontics and Periodontics. Piracicaba. BR
  • Taiete, Tiago; University of Campinas. Piracicaba Dental School. Department of Prosthodontics and Periodontics. Piracicaba. BR
  • Casati, Márcio Zaffalon; University of Campinas. Piracicaba Dental School. Department of Prosthodontics and Periodontics. Piracicaba. BR
  • Sallum, Enílson Antônio; University of Campinas. Piracicaba Dental School. Department of Prosthodontics and Periodontics. Piracicaba. BR
  • Nociti Júnior, Francisco Humberto; University of Campinas. Piracicaba Dental School. Department of Prosthodontics and Periodontics. Piracicaba. BR
  • Silvério, Karina Gonzales; University of Campinas. Piracicaba Dental School. Department of Prosthodontics and Periodontics. Piracicaba. BR
  • Casarin, Renato Corrêa Viana; University of Campinas. Piracicaba Dental School. Department of Prosthodontics and Periodontics. Piracicaba. BR
Braz. j. oral sci ; 20: e211654, jan.-dez. 2021. ilus
Article in English | LILACS, BBO | ID: biblio-1254524
Responsible library: BR218.1
ABSTRACT
Grade C periodontitis in youngers is characterized by a severe form of periodontitis, and IL10 rs6667202 single nucleotide polymorphism (SNP) has been described as an important feature in this disease etiology.

Aim:

This study aimed to evaluate, in vivo, the functionality of IL10 rs6667202 SNP on IL-10 gingival fluid levels.

Methods:

Thirty patients with Perio4C were selected, 15 with the IL10 AA genotype (rs6667202) and 15 with AC/CC genotypes. The gingival fluid was collected from two sites with probing depth ≥ 7 mm and bleeding on probing, and two healthy sites. The IL-10 concentration was determined by Luminex/MAGpix platform.

Results:

In deep pockets, the IL10 AA genotype presented a lower concentration of IL-10 when compared with AC or CC genotypes (p<0.05). In shallow pockets, no difference between groups was seen (p>0.05).

Conclusion:

IL10 rs6667202 SNP decreases the production of IL-10 in crevicular fluid, potentially affecting this disease progression
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Aggressive Periodontitis / Interleukin-10 / Polymorphism, Single Nucleotide Limits: Female / Humans / Male Language: English Journal: Braz. j. oral sci Journal subject: Dentistry Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Aggressive Periodontitis / Interleukin-10 / Polymorphism, Single Nucleotide Limits: Female / Humans / Male Language: English Journal: Braz. j. oral sci Journal subject: Dentistry Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of Campinas/BR