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Evaluation of the physicochemical equivalence of three brands of commercially available quinine sulphate tablets from South Western part of Nigeria
Adegbite, A. I; Adegbolagun, O. M.
  • Adegbite, A. I; s.af
  • Adegbolagun, O. M; s.af
Afr. health sci. (Online) ; 11(2): 197-203, 2011. ilus
Article in English | AIM | ID: biblio-1256405
ABSTRACT

BACKGROUND:

The relatively little resistance to quinine globally has led to an increase in its use in P. falciparum malaria especially in multi-drug resistant strains.

OBJECTIVE:

To evaluate the physicochemical and equivalency of three brands of quinine sulphate tablets available in South Western region of Nigeria.

METHODS:

The pharmaceutical and chemical equivalence of three brands of quinine sulphate tablets were assessed through the evaluation of some biopharmaceutical parameters and active drug content.

RESULTS:

All the brands complied with the official specification for uniformity of weight. Two of the brands (A & B) gave similar crushing strengths while the third brand (C) gave a much lower value. Similarly all the brands complied with the official specification of disintegration test but the obtained values were statistically different (p<0.05). The T(70) obtained from the dissolution rate profile was less than 45 minutes for the three brands, although A and B were not statistically different but C was statistically from A and B. The quinine content of brands B and C are within the official specification however brand A with percentage content of 110±1.3%w/w, is above the specification while it is statistically different from the other brands.

CONCLUSION:

Brands B and C could be regarded as chemical equivalent, but they are not biopharmaceutical equivalents, on the other hand, brands A and B may be regarded as biopharmaceutical equivalents but not chemical equivalent
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Index: AIM (Africa) Main subject: Malaria, Falciparum / Chemical Phenomena / Antimalarials / Nigeria Country/Region as subject: Africa Language: English Journal: Afr. health sci. (Online) Year: 2011 Type: Article

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Index: AIM (Africa) Main subject: Malaria, Falciparum / Chemical Phenomena / Antimalarials / Nigeria Country/Region as subject: Africa Language: English Journal: Afr. health sci. (Online) Year: 2011 Type: Article