Evaluation of the physicochemical equivalence of three brands of commercially available quinine sulphate tablets from South Western part of Nigeria
Afr. health sci. (Online)
;
11(2): 197-203, 2011. ilus
Article
in English
| AIM
| ID: biblio-1256405
ABSTRACT
BACKGROUND:
The relatively little resistance to quinine globally has led to an increase in its use in P. falciparum malaria especially in multi-drug resistant strains.OBJECTIVE:
To evaluate the physicochemical and equivalency of three brands of quinine sulphate tablets available in South Western region of Nigeria.METHODS:
The pharmaceutical and chemical equivalence of three brands of quinine sulphate tablets were assessed through the evaluation of some biopharmaceutical parameters and active drug content.RESULTS:
All the brands complied with the official specification for uniformity of weight. Two of the brands (A & B) gave similar crushing strengths while the third brand (C) gave a much lower value. Similarly all the brands complied with the official specification of disintegration test but the obtained values were statistically different (p<0.05). The T(70) obtained from the dissolution rate profile was less than 45 minutes for the three brands, although A and B were not statistically different but C was statistically from A and B. The quinine content of brands B and C are within the official specification however brand A with percentage content of 110±1.3%w/w, is above the specification while it is statistically different from the other brands.CONCLUSION:
Brands B and C could be regarded as chemical equivalent, but they are not biopharmaceutical equivalents, on the other hand, brands A and B may be regarded as biopharmaceutical equivalents but not chemical equivalent
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Index:
AIM (Africa)
Main subject:
Malaria, Falciparum
/
Chemical Phenomena
/
Antimalarials
/
Nigeria
Country/Region as subject:
Africa
Language:
English
Journal:
Afr. health sci. (Online)
Year:
2011
Type:
Article
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