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Inconclusive results with HIV serodiagnosis algorithms, and HIV-1 and HIV-2 co-infection in North-eastern Democratic Republic of Congo
Tonen-Wolyec, Serge; Batina, Agasa Salomon; Kumbati, Esperance; Tagota, Alliance; Ossinga, Bassandja Jacques; Kayembe, Tshilumba Charles; Belec, Laurent.
  • Tonen-Wolyec, Serge; s.af
  • Batina, Agasa Salomon; s.af
  • Kumbati, Esperance; s.af
  • Tagota, Alliance; s.af
  • Ossinga, Bassandja Jacques; s.af
  • Kayembe, Tshilumba Charles; s.af
  • Belec, Laurent; s.af
Afr. j. health issues ; 2(2): 1-6, 2018. ilus
Article in English | AIM | ID: biblio-1256876
ABSTRACT

Background:

Inconclusive serodiagnosis of HIV infection is particularly frequent in Central Africa. The aims of this study were to (i) determine the rate of inconclusive results with the two-test algorithm that the WHO proposed in 1997 (WHO II) versus the three-test algorithm (revised in 2012 and consolidated in 2015 by WHO) for HIV testing, and (ii) determine the prevalence of HIV-1 and HIV-2 co-infection in the north-eastern region of the Democratic Republic of the Congo (DRC).

Methods:

A multicentre cross-sectional study was performed between March and June 2016 in Kisangani and Bunia, the capital cities of Tshopo and Ituri provinces respectively. Alere Determine HIV-1/2 (Alere Medical Co. Ltd., Japan), Uni-GoldTM HIV (Trinity Biotech Manufacturing Ltd., Ireland) and recomLine HIV-1 and HIV-2 IgG (Biosynex, France) were the first, second and third tests in the serial algorithm.

Results:

The rate of inconclusive results was 1.1% (95% CI 0.4 to 3.1) with the two-test algorithm and 0.4% (95% CI 0.1 to 2.1) with the three-test algorithm (p less than 0.001). The prevalence of HIV-1 and HIV-2 co-infection among HIV positive sera was 16.7% (95% CI 4.7 to 44.8).

Conclusion:

The three-test algorithm HIV testing strategy significantly reduces the rate of inconclusive results. In addition, the prevalence of HIV-1 and HIV-2 co-infection is higher in a context where HIV-2 infection is poorly documented. Large-scale research is essential to clarify these

results:

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Index: AIM (Africa) Main subject: Democratic Republic of the Congo / Algorithms / AIDS Serodiagnosis / HIV Infections / HIV-1 / HIV-2 / Coinfection Type of study: Observational study / Risk factors Country/Region as subject: Africa Language: English Journal: Afr. j. health issues Year: 2018 Type: Article

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Index: AIM (Africa) Main subject: Democratic Republic of the Congo / Algorithms / AIDS Serodiagnosis / HIV Infections / HIV-1 / HIV-2 / Coinfection Type of study: Observational study / Risk factors Country/Region as subject: Africa Language: English Journal: Afr. j. health issues Year: 2018 Type: Article