Inconclusive results with HIV serodiagnosis algorithms, and HIV-1 and HIV-2 co-infection in North-eastern Democratic Republic of Congo
Afr. j. health issues
; 2(2): 1-6, 2018. ilus
Article
in En
| AIM
| ID: biblio-1256876
Responsible library:
CG1.1
ABSTRACT
Background:
Inconclusive serodiagnosis of HIV infection is particularly frequent in Central Africa. The aims of this study were to (i) determine the rate of inconclusive results with the two-test algorithm that the WHO proposed in 1997 (WHO II) versus the three-test algorithm (revised in 2012 and consolidated in 2015 by WHO) for HIV testing, and (ii) determine the prevalence of HIV-1 and HIV-2 co-infection in the north-eastern region of the Democratic Republic of the Congo (DRC).Methods:
A multicentre cross-sectional study was performed between March and June 2016 in Kisangani and Bunia, the capital cities of Tshopo and Ituri provinces respectively. Alere Determine HIV-1/2 (Alere Medical Co. Ltd., Japan), Uni-GoldTM HIV (Trinity Biotech Manufacturing Ltd., Ireland) and recomLine HIV-1 and HIV-2 IgG (Biosynex, France) were the first, second and third tests in the serial algorithm.Results:
The rate of inconclusive results was 1.1% (95% CI 0.4 to 3.1) with the two-test algorithm and 0.4% (95% CI 0.1 to 2.1) with the three-test algorithm (p less than 0.001). The prevalence of HIV-1 and HIV-2 co-infection among HIV positive sera was 16.7% (95% CI 4.7 to 44.8).Conclusion:
The three-test algorithm HIV testing strategy significantly reduces the rate of inconclusive results. In addition, the prevalence of HIV-1 and HIV-2 co-infection is higher in a context where HIV-2 infection is poorly documented. Large-scale research is essential to clarify theseresults:
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Index:
AIM
Main subject:
Democratic Republic of the Congo
/
Algorithms
/
AIDS Serodiagnosis
/
HIV Infections
/
HIV-1
/
HIV-2
/
Coinfection
Type of study:
Observational_studies
/
Risk_factors_studies
Country/Region as subject:
Africa
Language:
En
Journal:
Afr. j. health issues
Year:
2018
Type:
Article