Screening of metal ion chelators against Leishmania donovani-infected Syrian hamsters
Afr. j. health sci
; 2(1): 223-227, 1995.
Article
in En
| AIM
| ID: biblio-1257035
Responsible library:
CG1.1
ABSTRACT
Leishmania donovani-infected Syrian hamsters were treated intraperitoneally with 0.23 mmoles/kg/day of EDTA; EGTA; HEEDTA and 100 mg/kg/day of Pentostam R. The control group received 0.1 ml of phosphate buffered saline. After 30 days of treatment; the animals were sacrificed. Of the Pentostam-treated animals; 5 out 6 had negative spleen cultures; while all the chelator and PBS-treated ones yielded parasites. While all the Pentostam-treated hamsters yielded had negative bone marrow cultures; only 1 out of 6 HEEDTA-treated hamsters yielded parasites. Spleen; liver and bone marrow parasite-loads calculated from chelator-treated animals were consistently significantly higher than for Pentostam-treated animals. These results suggest that although metal ion chelators have some antileishmanial potential; their in vivo activity against L. donovani is low compared to Pentostam
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Index:
AIM
Main subject:
Leishmaniasis
/
Chelating Agents
/
Mesocricetus
/
Animals
Type of study:
Diagnostic_studies
/
Screening_studies
Language:
En
Journal:
Afr. j. health sci
Year:
1995
Type:
Article