The anticonvulsant and sedative properties of stems of Cissus quadrangularis in mice

ABSTRACT

Cissus quadrangularis Linn grows in Savannah areas in Africa (Cameroon; Mali; Mauritania; Senegal; etc). In traditional medicine; the plant is used to treat anorexia; asthma; sickle cells; colds; pains; malaria; asthma and as an analgesic. In vivo animal models of epilepsy (maximal electroshock; n-methyl -d-aspartate; pentylenetetrazol; isonicotinic hydrazid acid and strychnine -induced convulsions or turning behavior) and insomnia (diazepam -induced sleep) were used. The aqueous extract of the stems of C. quadrangularis strongly increased the total sleep time induced by diazepam (50 mg/kg i.p.). It also protected mice against maximal electroshock; pentylenetetrazol; strychnine and n-methyl-d-aspartate-induced seizures or turning behavior and delayed the onset time of seizures induced by isonicotinic hydrazid acid. The results lead to the conclusion that the extract of C. quadrangularis possesses anticonvulsant and sedative properties in mice and could explain its use in traditional medicine in Africa; in the treatment of insomnia and epilepsy