Correlation of Serum Anti-Helicobacter pylori Immunoglobulin A (IGA) with Histological Parameters of Chronic Gastritis in Ibadan; Nigeria
Annals of Ibadan Postgraduate Medicine
;
10(1): 18-24, 2012.
Article
in English
| AIM
| ID: biblio-1259371
ABSTRACT
Background:
The seroprevalence of anti-H. pylori IgA antibodies has been reported to vary among populations and in relation to strains of Helicobacter pylori bacterium. However; there has been conflicting reports on the association between IgA serological status and the histological variables of chronic gastritis. This study was therefore conducted to clarify this relationship.Method:
Using an ELISA based commercial kit; anti-H. pylori IgA antibody tests were performed on 65 dyspeptic patients and 65 age- and ex-matched controls. The gastric biopsies of these patients were also examined histologically for the degrees of inflammation; activity; intestinal metaplasia and atrophy. The CagA status of the patients had been determined previously.Results:
There was an anti-H. pylori IgA antibody prevalence of 67.7in dyspeptics and 56.9in non-dyspeptic individuals. No correlations were observed between serum H. pylori IgA antibody and the graded parameters of chronic gastritis in dyspeptic patients; although twice more patients with mild gastric inflammation were found among IgA positive than among IgA negative patients. However; a statistically significant relationship was established between serum IgA positivity and the CagA status of the patients (p = 0.028).Conclusion:
The seroprevalence of anti-H. pylori IgA antibody is high in our environment. Serum IgA status may be associated with milder degrees of gastritis in our patients but a larger cohort of patients is needed to confirm this. There seems to be a good agreement between serum IgA and CagA statuses among dyspeptic patients
Full text:
Available
Index:
AIM (Africa)
Main subject:
Immunoglobulin A
/
Helicobacter pylori
/
Gastritis
Type of study:
Risk factors
Language:
English
Journal:
Annals of Ibadan Postgraduate Medicine
Year:
2012
Type:
Article
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